Literature DB >> 7455696

Type III hyperlipoproteinemia: defective metabolism of an abnormal apolipoprotein E.

R E Gregg, L A Zech, E J Schaefer, H B Brewer.   

Abstract

The apolipoprotein E isolated from plasma of individuals with type III hyperlipoproteinemia (HLP) shows an abnormal pattern when it is examined by isoelectric focusing. Compared to apolipoprotein E from normal subjects, apolipoprotein E isolated from subjects with type III HLP had a decreased fractional catabolic rate in vivo in both type III HLP patients and normal individuals. The delayed catabolism of apolipoprotein E in type III HLP patients may be responsible for the lipid and lipoprotein abnormalities characteristic of these patients.

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Year:  1981        PMID： 7455696     DOI： 10.1126/science.7455696

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  29 in total

1.  Hypercholesterolemia and Dyslipidemia.

Authors: 
Journal:  Curr Treat Options Cardiovasc Med       Date:  2000-04

2.  Liver-directed gene transfer and prolonged expression of three major human ApoE isoforms in ApoE-deficient mice.

Authors:  K Tsukamoto; P Smith; J M Glick; D J Rader
Journal:  J Clin Invest       Date:  1997-07-01       Impact factor: 14.808

3.  A physiologically based in silico kinetic model predicting plasma cholesterol concentrations in humans.

Authors:  Niek C A van de Pas; Ruud A Woutersen; Ben van Ommen; Ivonne M C M Rietjens; Albert A de Graaf
Journal:  J Lipid Res       Date:  2012-09-29       Impact factor: 5.922

4.  Postprandial plasma retinyl ester response is greater in older subjects compared with younger subjects. Evidence for delayed plasma clearance of intestinal lipoproteins.

Authors:  S D Krasinski; J S Cohn; E J Schaefer; R M Russell
Journal:  J Clin Invest       Date:  1990-03       Impact factor: 14.808

5.  Effects of APOC3 Heterozygous Deficiency on Plasma Lipid and Lipoprotein Metabolism.

Authors:  Gissette Reyes-Soffer; Carol Sztalryd; Richard B Horenstein; Stephen Holleran; Anastasiya Matveyenko; Tiffany Thomas; Renu Nandakumar; Colleen Ngai; Wahida Karmally; Henry N Ginsberg; Rajasekhar Ramakrishnan; Toni I Pollin
Journal:  Arterioscler Thromb Vasc Biol       Date:  2019-01       Impact factor: 8.311

6.  Apolipoprotein E polymorphism and atherosclerosis: insight from a study in octogenarians.

Authors:  J Davignon; D Bouthillier; A C Nestruck; C F Sing
Journal:  Trans Am Clin Climatol Assoc       Date:  1988

7.  Intestinal cholesterol absorption efficiency in man is related to apoprotein E phenotype.

Authors:  Y A Kesäniemi; C Ehnholm; T A Miettinen
Journal:  J Clin Invest       Date:  1987-08       Impact factor: 14.808

8.  Metabolism of apolipoproteins B-48 and B-100 of triglyceride-rich lipoproteins in patients with familial dysbetalipoproteinemia.

Authors:  A F Stalenhoef; M J Malloy; J P Kane; R J Havel
Journal:  J Clin Invest       Date:  1986-09       Impact factor: 14.808

9.  Increased prevalence of apolipoprotein E4 in type V hyperlipoproteinemia.

Authors:  G Ghiselli; E J Schaefer; L A Zech; R E Gregg; H B Brewer
Journal:  J Clin Invest       Date:  1982-08       Impact factor: 14.808

10.  Abnormal in vivo metabolism of apolipoprotein E4 in humans.

Authors:  R E Gregg; L A Zech; E J Schaefer; D Stark; D Wilson; H B Brewer
Journal:  J Clin Invest       Date:  1986-09       Impact factor: 14.808
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