Literature DB >> 7454623

3-(p-Chlorophenyl)-4-aminobutanoic acid--resolution into enantiomers and pharmacological activity.

B Witczuk, R A Khaunina, G Kupryszewski.   

Abstract

Racemic 3-(p-chlorophenyl)-4-aminobutanoic acid was resolved into enantiomers and their absolute configuration determined. Pharmacological activity of hydrochlorides of the racemic acid and its enantiomers has been determined. The R(+) enantiomer was found to be 4.2-9.2-fold as effective as the S(-) one and 1.4-1.9-fold as effective as the racemate.

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Year:  1980        PMID： 7454623

Source DB:  PubMed          Journal:  Pol J Pharmacol Pharm        ISSN： 0301-0244


  4 in total

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Journal:  Pharmacol Biochem Behav       Date:  2006-06-19       Impact factor: 3.533

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Authors:  Chelsea R Kasten; Shelby N Blasingame; Stephen L Boehm
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3.  Non-genetic factors that influence methamphetamine intake in a genetic model of differential methamphetamine consumption.

Authors:  A M Stafford; C Reed; T J Phillips
Journal:  Psychopharmacology (Berl)       Date:  2020-08-24       Impact factor: 4.530

4.  Application of high-resolution mass spectrometry to determination of baclofen in a case of fatal intoxication.

Authors:  Paweł Szpot; Agnieszka Chłopaś; Grzegorz Buszewicz; Grzegorz Teresiński
Journal:  Forensic Toxicol       Date:  2016-03-29       Impact factor: 4.096
  4 in total

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