Kinetics of drug decomposition. Part 62. Kinetics of penicillin G potassium salt (PGP) thermal degradation in solid phase.

The kinetics of degradation of penicillin G K salt (PGP) in solid phase in the temperature range 70-140 degrees C were investigated. The obtained sigmoidal curves were interpreted in terms of the Prout-Tompkins kinetics. The appropriate mathematical equations were derived for the induction and acceleration periods which enable to calculate the degradation half-time, t0.1 value and the induction time (t'). The Arrhenius plot shows the isokinetic point where the rates of reaction for both periods are identical.