Literature DB >> 7454230

Aetiology of jaagsiekte: experimental transmission to lambs by means of cultured cells and cell homogenates.

D W Verwoerd, E M De Villiers, R C Tustin.   

Abstract

Studies on the transmission of jaagsiekte (ovine pulmonary adenomatosis) both by subinoculation of cells of known sex and by cell homogenates into male and female lambs are reported. The results obtained indicate a thymocyte-dependent rejection of male cells in female recipients in contrast to the successful transplantation of male cells in male animals and female cells in both sexes. This suggests the presence of a surface antigen determined by the gamma-chromosome in the tumour cells. A second mechanism of transmission, dependent on the transformation of the recipient's cells, was demonstrated by 2 cases of heterologous transplantation and confirmed by inoculation of cellular homogenates.

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Mesh：

Year:  1980        PMID： 7454230

Source DB:  PubMed          Journal:  Onderstepoort J Vet Res        ISSN： 0030-2465            Impact factor:   1.792


  8 in total

1.  Unique long terminal repeat U3 sequences distinguish exogenous jaagsiekte sheep retroviruses associated with ovine pulmonary carcinoma from endogenous loci in the sheep genome.

Authors:  J Bai; R Y Zhu; K Stedman; C Cousens; J Carlson; J M Sharp; J C DeMartini
Journal:  J Virol       Date:  1996-05       Impact factor: 5.103

2.  Direct transformation of rodent fibroblasts by jaagsiekte sheep retrovirus DNA.

Authors:  N Maeda; M Palmarini; C Murgia; H Fan
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-10       Impact factor: 11.205

3.  A phosphatidylinositol 3-kinase docking site in the cytoplasmic tail of the Jaagsiekte sheep retrovirus transmembrane protein is essential for envelope-induced transformation of NIH 3T3 cells.

Authors:  M Palmarini; N Maeda; C Murgia; C De-Fraja; A Hofacre; H Fan
Journal:  J Virol       Date:  2001-11       Impact factor: 5.103

4.  Fusogenicity of Jaagsiekte sheep retrovirus envelope protein is dependent on low pH and is enhanced by cytoplasmic tail truncations.

Authors:  Marceline Côté; Yi-Min Zheng; Lorraine M Albritton; Shan-Lu Liu
Journal:  J Virol       Date:  2007-12-19       Impact factor: 5.103

5.  Transformation of rodent fibroblasts by the jaagsiekte sheep retrovirus envelope is receptor independent and does not require the surface domain.

Authors:  Yen-Hung J Chow; Alberto Alberti; Manuela Mura; Carla Pretto; Pablo Murcia; Lorraine M Albritton; Massimo Palmarini
Journal:  J Virol       Date:  2003-06       Impact factor: 5.103

6.  Multiple domains of the Jaagsiekte sheep retrovirus envelope protein are required for transformation of rodent fibroblasts.

Authors:  Andrew Hofacre; Hung Fan
Journal:  J Virol       Date:  2004-10       Impact factor: 5.103

7.  Putative phosphatidylinositol 3-kinase (PI3K) binding motifs in ovine betaretrovirus Env proteins are not essential for rodent fibroblast transformation and PI3K/Akt activation.

Authors:  Shan-Lu Liu; Michael I Lerman; A Dusty Miller
Journal:  J Virol       Date:  2003-07       Impact factor: 5.103

8.  Jaagsiekte sheep retrovirus biology and oncogenesis.

Authors:  Andrew Hofacre; Hung Fan
Journal:  Viruses       Date:  2010-12-03       Impact factor: 5.048
  8 in total

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