| Literature DB >> 7452697 |
G E Stokker, A A Deana, S J deSolms, E M Schultz, R L Smith, E J Cragoe, J E Baer, C T Ludden, H F Russo, A Scriabine, C S Sweet, L S Watson.
Abstract
A series of 2-(aminomethyl)phenols was synthesized and tested in rats and dogs for saluretic and diuretic activity. A number of these compounds exhibit a high order of activity on iv or po administration. The most active compounds belong to a subseries of 4-alkyl-6-halo derivatives of which 2, 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenol, is the most active. Compound 2 also possesses significant antihypertensive activity, an adjunctive pharmacological parameter which distinguishes 2 from the other compounds prepared in this series. In addition, 2 displays both topical saluretic and antiinflammatory activities.Entities:
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Year: 1980 PMID： 7452697 DOI： 10.1021/jm00186a024
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446