| Literature DB >> 7452694 |
R Buchman, J A Scozzie, Z S Ariyan, R D Heilman, D J Rippin, W J Pyne, L J Powers, R J Matthews.
Abstract
The synthesis of a series of 5,6-diarylpyridazinones is described. Some members of this series display an antihypertensive effect in both the spontaneously hypertensive rat (SHR) model and the deoxycorticosteroid (DOCA) model of hypertension. The most potent compounds in the series have halogen substituents on the 5,6-diphenyl rings, a beta-substituted alkyl group at the 2 position of the ring, and acetyl or cyano substituent at the 4 position.Entities:
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Year: 1980 PMID： 7452694 DOI： 10.1021/jm00186a021
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446