| Literature DB >> 7452680 |
J A Grosso, D E Nichols, M B Nichols, G K Yim.
Abstract
Based on the known biological activity of a variety of guanidine-containing agents, several N-substituted 3,4-dihydroquinazolines were synthesized. These compounds can be considered to be rigid analogues of phenylguanidines. In anesthetized rats the compounds decreased blood pressure and were antagonists of the pressor response to norepinephrine.Entities:
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Year: 1980 PMID： 7452680 DOI： 10.1021/jm00185a026
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446