Literature DB >> 7452470

Novel potential anticancer agents derived from benzimidazole.

E S Ibrahim, A M Omar, M A Khalil.   

Abstract

Two novel series of benzimidazole derivatives bearing structural modifications of certain drugs were prepared for evaluation for potential anticancer activity. The first series was a group of alkylating agents, and the second series was a variety of 4-substituted-1-thioacetyl-3-thiosemicarbazides. The tests of some representative products for antileukemic activity against P-388 lymphocytic leukemia indicated no significant effects.

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Year:  1980        PMID: 7452470     DOI: 10.1002/jps.2600691130

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN: 0022-3549            Impact factor:   3.534


  2 in total

1.  Synthesis, characterization, anti-ulcer action and molecular docking evaluation of novel benzimidazole-pyrazole hybrids.

Authors:  Abida Noor; Neelum Gul Qazi; Humaira Nadeem; Arif-Ullah Khan; Rehan Zafar Paracha; Fawad Ali; Adil Saeed
Journal:  Chem Cent J       Date:  2017-09-02       Impact factor: 4.215

2.  1-benzyl-2-phenylbenzimidazole (BPB), a benzimidazole derivative, induces cell apoptosis in human chondrosarcoma through intrinsic and extrinsic pathways.

Authors:  Ju-Fang Liu; Yuan-Li Huang; Wei-Hung Yang; Chih-Shiang Chang; Chih-Hsin Tang
Journal:  Int J Mol Sci       Date:  2012-12-04       Impact factor: 5.923

  2 in total

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