Literature DB >> 7452266

Uptake of L-[35S]cystine by isolated rat brain capillaries.

S M Hwang, S Weiss, S Segal.   

Abstract

Adult rat brain capillaries were isolated by a simplified procedure and showed an enrichment of the marker enzyme, gamma-glutamyltranspeptidase. The uptake of [35S]cystine at 37 degrees C by this preparation can be divided into two components, a sodium- and energy-dependent transport process for the free amino acid pool, with an apparent Km of 36 microM, and a binding process, with an apparent Km of 1.13 mM. Chemical analysis of the amino acid pool indicates that cystine is the major from of intracapillary 35S. Cystine transport was not inhibited by lysine, but glycine, alpha-methylaminoisobutyric acid and beta-2-aminobicyclo-[2,2,1]-heptane-2-carboxylic acid were inhibitory to a small extent.

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Year:  1980        PMID： 7452266     DOI： 10.1111/j.1471-4159.1980.tb06281.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  6 in total

1.  Brain gamma-glutamyltranspeptidase: characteristics, development and thyroid hormone dependency of the enzyme in isolated microvessels and neuronal/glial cell plasma membranes.

Authors:  S J Hemmings; K B Storey
Journal:  Mol Cell Biochem       Date:  1999-12       Impact factor: 3.396

2.  Purification and characterization of metabolically active capillaries of the blood-brain barrier.

Authors:  L Dallaire; L Tremblay; R Béliveau
Journal:  Biochem J       Date:  1991-06-15       Impact factor: 3.857

3.  Gamma-glutamyl transpeptidase does not act as a cystine transporter in brain microvessels.

Authors:  J E Wolff; G Münstermann; K Grebenkämper; M Erben
Journal:  Neurochem Res       Date:  1998-09       Impact factor: 3.996

4.  Dietary manipulation with high marine fish oil intake of fatty acid composition and arachidonic acid metabolism in rat cerebral microvessels.

Authors:  J Kálmán; A Gecse; T Farkas; F Joó; G Telegdy; A Lajtha
Journal:  Neurochem Res       Date:  1992-02       Impact factor: 3.996

Review 5.  The Blood-Brain Barrier, an Evolving Concept Based on Technological Advances and Cell-Cell Communications.

Authors:  Camille Menaceur; Fabien Gosselet; Laurence Fenart; Julien Saint-Pol
Journal:  Cells       Date:  2021-12-31       Impact factor: 6.600

6.  Non-type I cystinuria associated with mental retardation and ataxia in a Korean boy with a new missence mutation(G173R) in the SLC7A9 gene.

Authors:  Eun Ha Lee; Yeun Hee Kim; Jin Soon Hwang; Sung Hwan Kim
Journal:  J Korean Med Sci       Date:  2009-12-26       Impact factor: 2.153
  6 in total

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