Literature DB >> 7451550

Dose-dependent effect of trichloropropene oxide on benzo[a]pyrene carcinogenesis.

M Kodama, Y Ioki, C Nagata.   

Abstract

The epoxide hydratase inhibitor, 1,1,1-trichloro-2,3-propene oxide (TCPO) in combination with benzo[a]pyrene (B[a]P) was injected s.c. in ddN mice. The formation of fibrosarcoma by B[a]P was slightly accelerated at low dose of TCPO, and remarkably inhibited at high dose of TCPO. The correlation of carcinogenesis with B[a]P metabolism was discussed.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 7451550     DOI： 10.1007/bf00413182

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  7 in total

1.  Benzo(a)pyrene metabolism in mouse epidermis. Analysis by high pressure liquid chromatography and DNA binding.

Authors:  D L Berry; W R Bracken; T J Slaga; N M Wilson; S G Butty; M R Juchau
Journal:  Chem Biol Interact       Date:  1977-08       Impact factor: 5.192

Review 2.  Tumor-promoting agents in two-stage carcinogenesis.

Authors:  B L Van Duuren
Journal:  Prog Exp Tumor Res       Date:  1969

3.  Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide.

Authors:  P Sims; P L Grover; A Swaisland; K Pal; A Hewer
Journal:  Nature       Date:  1974-11-22       Impact factor: 49.962

4.  Lack of effect of trichloropropene oxide on benzo(a)pyrene tumor-initiating activity on mouse skin.

Authors:  K Alexandrov; P M Dansette; M Flodrops; C Frayssinet
Journal:  Eur J Cancer       Date:  1979-01       Impact factor: 9.162

5.  Effect of trichloropropene oxide and benzoflavone on polycyclic hydrocarbon carcinogenesis in C3H/He and DBA/2 mice.

Authors:  M Watanabe; K Watanabe; H Sato
Journal:  Gan       Date:  1979-02

6.  Effect of trichloropropene oxide on the ability of polyaromatic hydrocarbons and their "K-region" oxides to initiate skin tumors in mice and to bind to DNA in vitro.

Authors:  D L Berry; T J Slaga; A Viaje; N M Wilson; J DiGiovanni; M R Juchau; J K Selkirk
Journal:  J Natl Cancer Inst       Date:  1977-04       Impact factor: 13.506

7.  The binding to mouse skin DNA of benzo[a]pyrene, its 7,8-diol and 7,8-diol-9,10-epoxides in relation to the tumorigenicity of these compounds.

Authors:  P Brookes
Journal:  Cancer Lett       Date:  1979-04       Impact factor: 8.679
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.