Literature DB >> 7450929

Interaction of phenylbutazone and tolbutamide in man.

M Szita, B Gachályi, M Tornyossy, A Káldor.   

Abstract

Phenylbutazone pretreatment increases tolbutamide half-life, whereas tolbutamide pretreatment decreases phenylbutazone half-life in man. Clinically, phenylbutazone may enhance the hypoglycemic action of tolbutamide, and tolbutamide may reduce the therapeutic effect of phenylbutazone.

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Year:  1980        PMID: 7450929

Source DB:  PubMed          Journal:  Int J Clin Pharmacol Ther Toxicol        ISSN: 0174-4879


  2 in total

1.  Tenidap sodium does not alter the clearance or plasma protein binding of tolbutamide in healthy male volunteers.

Authors:  K D Wilner; M J Gardner
Journal:  Br J Clin Pharmacol       Date:  1995       Impact factor: 4.335

Review 2.  Antihyperglycaemic agents. Drug interactions of clinical importance.

Authors:  A J Scheen; P J Lefèbvre
Journal:  Drug Saf       Date:  1995-01       Impact factor: 5.606

  2 in total

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