Literature DB >> 7450019

A non steroidal anti-inflammatory drug that stimulates prostaglandin release.

P Pomarelli, M Berti, M T Gatti, P Mosconi.   

Abstract

Diacetylrhein (DAR) is a new anti-inflammatory and anti-osteoarthritic drug. Studies with isolated lung preparation showed that DAR does not exert its action by inhibiting the arachidonic acid metabolism. Furthermore, the in vivo experiments showed that DAR, contrary to most anti-inflammatory drugs, induced an increase of prostaglandin-like substances in the rat exudates. The above results are substantiated by experimental evidence that in the rat this compound displays a dose-dependent protecting activity against indomethacin-induced gastric damage.

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Year:  1980        PMID： 7450019

Source DB:  PubMed          Journal:  Farmaco Sci        ISSN： 0430-0920


  8 in total

1.  Effects of diacerein at the molecular level in the osteoarthritis disease process.

Authors:  Johanne Martel-Pelletier; Jean-Pierre Pelletier
Journal:  Ther Adv Musculoskelet Dis       Date:  2010-04       Impact factor: 5.346

2.  The effect and safety of diacerein in patients with type 2 diabetes mellitus : a systematic review and meta-analysis.

Authors:  Qi Zhang; Junteng Zhou; Yushu Wang; Decai Chen
Journal:  Am J Clin Exp Immunol       Date:  2017-12-20

3.  Rhein inhibits interleukin-1 beta-induced activation of MEK/ERK pathway and DNA binding of NF-kappa B and AP-1 in chondrocytes cultured in hypoxia: a potential mechanism for its disease-modifying effect in osteoarthritis.

Authors:  Grégoire Martin; Patrick Bogdanowicz; Florence Domagala; Hervé Ficheux; Jean-Pierre Pujol
Journal:  Inflammation       Date:  2003-08       Impact factor: 4.092

Review 4.  Diacerein.

Authors:  C M Spencer; M I Wilde
Journal:  Drugs       Date:  1997-01       Impact factor: 9.546

5.  Dystrophic phenotype improvement in the diaphragm muscle of mdx mice by diacerhein.

Authors:  Rafael Dias Mâncio; Túlio de Almeida Hermes; Aline Barbosa Macedo; Daniela Sayuri Mizobuti; Ian Feller Rupcic; Elaine Minatel
Journal:  PLoS One       Date:  2017-08-07       Impact factor: 3.240

6.  Effects of rhein on renal arachidonic acid metabolism and renal function in patients with congestive heart failure.

Authors:  G La Villa; F Marra; G Laffi; B Belli; E Meacci; P Fascetti; P Gentilini
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953

7.  Influence of renal function on the pharmacokinetics of diacerein after a single oral dose.

Authors:  P Debord; K Louchahi; M Tod; A Cournot; G Perret; O Petitjean
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1994 Jan-Mar       Impact factor: 2.441

Review 8.  Clinical pharmacokinetics of diacerein.

Authors:  P Nicolas; M Tod; C Padoin; O Petitjean
Journal:  Clin Pharmacokinet       Date:  1998-11       Impact factor: 6.447
  8 in total

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