Literature DB >> 7449835

Stimulation of adenylate cyclase in rat striatum by pergolide: influence of GTP.

M R Rosenfeld, M H Makman, M Goldstein.   

Abstract

Pergolide stimulates adenylate cyclase activity in homogenates of rat striatum. In contrast, bromocriptine and lisuride are inactive. GTP enhances the stimulation produced by pergolide and has no effect on the other ergots tested. The stimulation produced by pergolide is inhibited by haloperidol but not by molindone. It is concluded that pergolide acts as an agonist at dopaminergic receptors coupled to adenylate cyclase in rat striatum.

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Year:  1980        PMID： 7449835     DOI： 10.1016/0014-2999(80)90062-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  4 in total

1.  Postsynaptic bimodal effect of sulpiride on locomotor activity induced by pergolide in catecholamine-depleted mice.

Authors:  M Rubinstein; O Gershanik; F J Stefano
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-01       Impact factor: 3.000

Review 2.  Hypothesis: bromocriptine lacks intrinsic dopamine receptor stimulating properties.

Authors:  D M Jackson; O F Jenkins
Journal:  J Neural Transm       Date:  1985       Impact factor: 3.575

3.  Effect of a stereospecific D2-dopamine agonist on acetylcholine concentration in corpus striatum of rat brain.

Authors:  D T Wong; F P Bymaster; L R Reid; R W Fuller; K W Perry; E C Kornfeld
Journal:  J Neural Transm       Date:  1983       Impact factor: 3.575

4.  Mesulergine and pergolide in previously untreated Parkinson's disease.

Authors:  A Wright; A J Lees; G M Stern
Journal:  J Neurol Neurosurg Psychiatry       Date:  1987-04       Impact factor: 10.154
  4 in total

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