Literature DB >> 7449830

Effects of GABA and diazepam on 3H-serotonin release from hippocampal synaptosomes.

D J Balfour.   

Abstract

The effects of GABA and diazepam on the spontaneous and potassium-evoked release of 3H-5-HT from rat hippocampal synaptosomes, preloaded by incubation with 3H-5-HT, have been investigated. Both GABA and diazepam independently increased the spontaneous release of 5-HT whereas they blocked the calcium-dependent, potassium-evoked release. However diazepam antagonised the GABA-mediated increase in spontaneous release but enhanced the inhibitory effects of GABA on potassium-stimulated release. The results suggest that 5-HT release in the hippocampus is under the presynaptic control of GABA and that diazepam may selectively enhance the inhibitory effect of GABA on the evoked release of 5-HT.

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Year:  1980        PMID： 7449830     DOI： 10.1016/0014-2999(80)90054-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

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Authors:  H Kabuto; I Yokoi; A Mori
Journal:  Neurochem Res       Date:  1988-12       Impact factor: 3.996

3.  Effect of established and putative anxiolytics on extracellular 5-HT and 5-HIAA in the ventral hippocampus of rats during behaviour on the elevated X-maze.

Authors:  I K Wright; N Upton; C A Marsden
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

4.  The profiles of interaction of yohimbine with anxiolytic and putative anxiolytic agents to modify 5-HT release in the frontal cortex of freely-moving rats.

Authors:  C H Cheng; B Costall; J Ge; R J Naylor
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

5.  Effect of diazepam on cortical 5-HT release and behaviour in the guinea-pig on exposure to the elevated plus maze.

Authors:  A Rex; C A Marsden; H Fink
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

6.  The effects of methyl beta-carboline-3-carboxylate on social interaction and locomotor activity when microinjected into the nucleus raphé dorsalis of the rat.

Authors:  S W Hindley; A Hobbs; I A Paterson; M H Roberts
Journal:  Br J Pharmacol       Date:  1985-11       Impact factor: 8.739

7.  GABAB receptor-mediated inhibition of serotonin release in the rat brain.

Authors:  E Schlicker; K Classen; M Göthert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-06       Impact factor: 3.000
  7 in total

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