Literature DB >> 7449790

Phenytoin elimination kinetics in two children with drug intoxication.

K Abe, M Okano, H Sasaki.   

Abstract

Two girls aged 6 and 10 years treated with anticonvulsants developed nystagmus and ataxia. The peak plasma concentrations of phenytoin were 42.6 and 46.6 microgram/ml, respectively, compatible with phenytoin toxicity. The decline in plasma phenytoin levels did not fit first order kinetics, but followed Michaelis-Menten kinetics.

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Year:  1980        PMID： 7449790     DOI： 10.1007/bf00445896

Source DB:  PubMed          Journal:  Eur J Pediatr        ISSN： 0340-6199            Impact factor:   3.183


  8 in total

1.  Phenytoin kinetics in children.

Authors:  R G Curless; P D Walson; D E Carter
Journal:  Neurology       Date:  1976-08       Impact factor: 9.910

2.  Pharmacokinetic study of a patient with diphenylhydantoin toxicity.

Authors:  A J Atkinson; J M Shaw
Journal:  Clin Pharmacol Ther       Date:  1973 Jul-Aug       Impact factor: 6.875

3.  Explanation of dose-dependent decline of diphenylhydantoin plasma levels by fitting to the integrated form of the Michaelis-Menten equation.

Authors:  N Gerber; J G Wagner
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1972-05

4.  Concurrent administration of phenobarbital and diphenylhydantoin: lack of an interference effect.

Authors:  H E Booker; A Tormey; J Toussaint
Journal:  Neurology       Date:  1971-04       Impact factor: 9.910

5.  The clinical pharmacokinetics of phenytoin.

Authors:  E Martin; T N Tozer; L B Sheiner; S Riegelman
Journal:  J Pharmacokinet Biopharm       Date:  1977-12

6.  Diphenylhydantoin elimination kinetics in overdosed children.

Authors:  L K Garrettson; W J Jusko
Journal:  Clin Pharmacol Ther       Date:  1975-04       Impact factor: 6.875

7.  The elimination of phenytoin in man.

Authors:  M J Eadie; J H Tyrer; F Bochner; W D Hooper
Journal:  Clin Exp Pharmacol Physiol       Date:  1976 May-Jun       Impact factor: 2.557

8.  The rate of decline of diphenylhydantoin in human plasma.

Authors:  K Arnold; N Gerber
Journal:  Clin Pharmacol Ther       Date:  1970 Jan-Feb       Impact factor: 6.903
  8 in total
  3 in total

Review 1.  Drug-induced cerebellar ataxia: a systematic review.

Authors:  J van Gaalen; F G Kerstens; R P P W M Maas; L Härmark; B P C van de Warrenburg
Journal:  CNS Drugs       Date:  2014-12       Impact factor: 5.749

Review 2.  Clinical features and management of poisoning due to phenytoin.

Authors:  J R Larsen; L S Larsen
Journal:  Med Toxicol Adverse Drug Exp       Date:  1989 Jul-Aug

Review 3.  Phenytoin poisoning.

Authors:  Simon Craig
Journal:  Neurocrit Care       Date:  2005       Impact factor: 3.210
  3 in total

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