Growth kinetics of ataxia telangiectasia lymphoblastoid cells. Evidence for a prolonged S period.

Growth rates were investigated in long-term lymphoblastoid cell lines derived from normal individuals and patients with ataxia telangiectasia (ATR). By a cell doubling method, sister chromatid exchanges, and autoradiography, the ATR cells showed a significantly longer total generation time. Autoradiography demonstrated that the difference in cell cycle was due to a specific lengthening of the S period in the ATR lymphoblasts.