Literature DB >> 7449299

beta-Adrenoreceptor-blocking agents and the blood-brain barrier.

J M Cruickshank, G Neil-Dwyer, M M Cameron, J McAinsh.   

Abstract

1. Sixteen neurosurgical patients received (oral) beta-adrenoreceptor-blocking agents (beta-receptor blockers) for 3-22 days. 2. Lipophilic beta-receptor blockers (propranolol) and metoprolol appeared in cerebrospinal fluid at concentrations similar to the free drug plasma concentration. 3. Cerebrospinal fluid concentrations of beta-receptor blockers were poor predictors of brain concentrations. 4. Both lipophilic beta-receptor blockers appeared in high concentrations in the brain: the brain/plasma ratio was approximately 15:1. 5. Hydrophilic atenolol appeared at low concentrations in brain tissue (about 20 times lower than the lipophilic beta-receptor blockers): the brain/plasma ratio was approximately 0.1:1. 6. Central nervous system-related side effects associated mainly with lipophilic beta-receptor blockers possibly result from high brain tissue concentrations.

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Year:  1980        PMID： 7449299     DOI： 10.1042/cs059453s

Source DB:  PubMed          Journal:  Clin Sci (Lond)        ISSN： 0143-5221            Impact factor:   6.124


  13 in total

1.  Attenuation of emotional and nonemotional memories after their reactivation: role of beta adrenergic receptors.

Authors:  J Przybyslawski; P Roullet; S J Sara
Journal:  J Neurosci       Date:  1999-08-01       Impact factor: 6.167

Review 2.  Retinal melatonin and dopamine in seasonal affective disorder.

Authors:  D A Oren
Journal:  J Neural Transm Gen Sect       Date:  1991

3.  Acquisition of Pavlovian fear conditioning using β-adrenoceptor activation of the dorsal premammillary nucleus as an unconditioned stimulus to mimic live predator-threat exposure.

Authors:  Eloisa Pavesi; Newton S Canteras; Antônio P Carobrez
Journal:  Neuropsychopharmacology       Date:  2011-01-05       Impact factor: 7.853

4.  Effects of atenolol, labetalol and propranolol on the peripheral circulation in hypertensive patients without obstructive vascular disease.

Authors:  E van der Veur; B S ten Berge; A A Wouda; H Wesseling
Journal:  Eur J Clin Pharmacol       Date:  1985       Impact factor: 2.953

5.  Atenolol reduces plasma melatonin concentration in man.

Authors:  P J Cowen; S Fraser; R Sammons; A R Green
Journal:  Br J Clin Pharmacol       Date:  1983-05       Impact factor: 4.335

6.  A recursive-partitioning model for blood-brain barrier permeation.

Authors:  S R Mente; F Lombardo
Journal:  J Comput Aided Mol Des       Date:  2005-12-06       Impact factor: 3.686

7.  Cardiovascular and phrenic nerve responses to stimulation of the amygdala central nucleus in the anaesthetized rabbit.

Authors:  G E Cox; D Jordan; J F Paton; K M Spyer; L M Wood
Journal:  J Physiol       Date:  1987-08       Impact factor: 5.182

8.  Receptor occupancy in lumbar CSF as a measure of the antagonist activity of atenolol, metoprolol and propranolol in the CNS.

Authors:  T Kaila; R Marttila
Journal:  Br J Clin Pharmacol       Date:  1993-05       Impact factor: 4.335

9.  Nonlinear distribution of atenolol between plasma and cerebrospinal fluid.

Authors:  F M Gengo; S C Fagan; L N Hopkins; D Wagner; D P Schuster
Journal:  Pharm Res       Date:  1989-03       Impact factor: 4.200

10.  Does the sympathetic nervous system influence sinus arrhythmia in man? Evidence from combined autonomic blockade.

Authors:  R Coker; A Koziell; C Oliver; S E Smith
Journal:  J Physiol       Date:  1984-11       Impact factor: 5.182
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