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Literature DB >> 7448120

A pyrogen derived from human white cells which is active in mice.

Abstract

An endogenous pyrogen smaller in molecular size than that previously obtained from human white cells has been found in supernatants of these cells after uptake of zymosan and incubation for 18 h. The new pyrogen after separation from other pyrogens which are produced at the same time has been found to produce fever in mice but not in rabbits. Because it is not formed if cycloheximide is present and is inactivated by leucine aminopeptidase, it is believed to be a peptide.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1980 PMID： 7448120 PMCID： PMC2041542

Source DB: PubMed Journal: Br J Exp Pathol ISSN： 0007-1021

15 in total

1. Nonisoelectric focusing in buffers.

Authors: N Y Nguyen; A Chrambach
Journal: Anal Biochem Date: 1976-07 Impact factor: 3.365

2. Electrofocusing in natural pH gradients formed by buffers: gradient modification.

Authors: N Y Nguyen; A Salokangas; A Chrambach
Journal: Anal Biochem Date: 1977-03 Impact factor: 3.365

3. Isoelectric focusing in layers of granulated gels. II. Preparative isoelectric focusing.

Authors: B J Radola
Journal: Biochim Biophys Acta Date: 1975-03-28

4. Further purification of rabbit leukocyte pyrogen.

Authors: P A Murphy; P J Chesney; W B Wood
Journal: J Lab Clin Med Date: 1974-02

5. A technique for quantitative measurement of endotoxin in human plasma.

Authors: R B Reinhold; J Fine
Journal: Proc Soc Exp Biol Med Date: 1971-05

6. Interactions of gram-negative bacterial endotoxin with rabbit blood in vitro.

Authors: E S Snell; E Atkins
Journal: Am J Physiol Date: 1967-05

7. An isotopic assay for NADPH oxidase activity and some characteristics of the enzyme from human polymorphonuclear leukocytes.

Authors: L R DeChatelet; L C McPhail; D Mullikin; C E McCall
Journal: J Clin Invest Date: 1975-04 Impact factor: 14.808

A pyrogen derived from human white cells which is active in mice.

1. Nonisoelectric focusing in buffers.

2. Electrofocusing in natural pH gradients formed by buffers: gradient modification.

3. Isoelectric focusing in layers of granulated gels. II. Preparative isoelectric focusing.

4. Further purification of rabbit leukocyte pyrogen.

5. A technique for quantitative measurement of endotoxin in human plasma.

6. Interactions of gram-negative bacterial endotoxin with rabbit blood in vitro.

7. An isotopic assay for NADPH oxidase activity and some characteristics of the enzyme from human polymorphonuclear leukocytes.

8. Pyrogen from mouse macrophages causes fever in mice.

9. The production of antibody against human leukocytic pyrogen.

10. Demonstration and characterization of two distinct human leukocytic pyrogens.

1. Interleukin 1 as mediator of the acute-phase response.

2. Studies on the active site of human leukocytic pyrogen.

Review 3. An update on human interleukin-1: from molecular biology to clinical relevance.