Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Ultrastructural observations on the pathogenesis of aspirin-induced gastric erosions.

Literature DB >> 7448118

Ultrastructural observations on the pathogenesis of aspirin-induced gastric erosions.

Abstract

It is shown by transmission electron-microscopy that the first structural change in rats, following a dose of aspirin, is to the basement membrane of the endothelial cell of the capillary and post-capillary venule. This leads to the breakdown of small blood vessels before any other cytolytic effect. This is a focal effect and it is proposed that the erosion develops as an ischaemic infarct.

Entities: Chemical Disease Species

Mesh：

Substances：
Aspirin

Year: 1980 PMID： 7448118 PMCID： PMC2041530

Source DB: PubMed Journal: Br J Exp Pathol ISSN： 0007-1021

17 in total

1. Role of gastric acid in aspirin-induced gastric irritation in the rat.

Authors: D A Brodie; B J Chase
Journal: Gastroenterology Date: 1967-10 Impact factor: 22.682

2. The gastric mucosal response to acetylsalicylic acid in the ferret. An ultrastructural study.

Authors: C J Pfeiffer; J Weibel
Journal: Am J Dig Dis Date: 1973-10

3. Aspirin induced gastric mucosal injury in rats and adenyl cyclase.

Authors: J C Mangla; Y M Kim; A A Rubulis
Journal: Biochem Med Date: 1974-12

4. The effects of acetic and acetylsalicylic acids on the appearance of the gastric mucosal surface epithelium in the scanning electron microscope.

Authors: B Frenning; K J Obrink
Journal: Scand J Gastroenterol Date: 1971 Impact factor: 2.423

5. Effect of aspirin and related compounds on the fine structure of mouse gastric mucosa.

Authors: D J Hingson; S Ito
Journal: Gastroenterology Date: 1971-08 Impact factor: 22.682

6. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

Authors: J R Vane
Journal: Nat New Biol Date: 1971-06-23

7. Role of gastric acid in aspirin-induced erosive gastritis.

Authors: A Gottschalk; R Menguy
Journal: Proc Soc Exp Biol Med Date: 1970-11

8. Role of inhibition of gastric mucous secretion in the phenomenon of gastric mucosal injury by indomethacin.

Authors: R Menguy; L Desbaillets
Journal: Am J Dig Dis Date: 1967-09

9. Morphology of gastrointestinal effects of aspirin.

Authors: K J Hahn; D Krischkofski; E Weber; E Morgenstern
Journal: Clin Pharmacol Ther Date: 1975-03 Impact factor: 6.875

10. Influence of achlorhydria on aspirin-induced occult gastrointestinal blood loss: studies in Addisonian pernicious anaemia.

Authors: D J John; F T McDermott
Journal: Br Med J Date: 1970-05-23

14 in total

4. Correlations between changes in indicators of gastric mucosal barrier integrity at time of exposure to "barrier breakers" and extent of hemorrhagic erosions one hour later.

Authors: G P Morris; J L Wallace; P L Harding; E J Krausse; S J Lolle
Journal: Dig Dis Sci Date: 1984-01 Impact factor: 3.199

5. Genetic and histological aspects of stomach lesions induced by systemic injection of phenylbutazone in the rat.

Authors: P Driscoll; P Kugler
Journal: Experientia Date: 1984-09-15

6. Relationship of gastric mucosal damage induced in pigs by antiinflammatory drugs to their effects on prostaglandin production.

Authors: K D Rainsford; C Willis
Journal: Dig Dis Sci Date: 1982-07 Impact factor: 3.199

7. Electron microscopic observations comparing the gastric mucosal damage induced in rats and pigs by benoxaprofen and aspirin, reflecting their differing actions as prostaglandin-synthesis-inhibitors.

Authors: K D Rainsford; C M Willis; S A Walker; P G Robins
Journal: Br J Exp Pathol Date: 1982-02