Literature DB >> 7448116

Prevention of neutrophil chemotactic deactivation by ascorbic acid.

F Patrone, F Dallegri, G Lanzi, C Sacchetti.   

Abstract

The locomotion of human neutrophils deactivated by pretreatment with appropriate concentration of chemoattractant was investigated in experimental conditions capable of dissociating random from truly directional motility. It was shown that deactivated neutrophils lose true chemotactic responsiveness, being unaffected by the rate of locomotion. Ascorbic acid, when present in appropriate concentrations during the deactivation step, completely prevented the loss of true chemotactic responsiveness by cells--that is, their chemotactic deactivation.

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Year:  1980        PMID： 7448116      PMCID： PMC2041532     

Source DB:  PubMed          Journal:  Br J Exp Pathol        ISSN： 0007-1021


  17 in total

Review 1.  Granulocyte-complement interaction. A beneficial antimicrobial mechanism that can cause disease.

Authors:  H S Jacob
Journal:  Arch Intern Med       Date:  1978-03

2.  Ascorbic acid levels in phagocytic cells.

Authors:  L R DeChatelet; C E McCall; M R Cooper; P S Shirley
Journal:  Proc Soc Exp Biol Med       Date:  1974-04

3.  A test of granulocyte membrane integrity and phagocytic function.

Authors:  F Dankberg; M D Persidsky
Journal:  Cryobiology       Date:  1976-08       Impact factor: 2.487

4.  Distinct chemokinetic and chemotactic responses in neutrophil granulocytes.

Authors:  H U Keller; J H Wissler; M W Hess; H Cottier
Journal:  Eur J Immunol       Date:  1978-01       Impact factor: 5.532

Review 5.  Biochemical mechanisms accounting for the toxic action of oxygen on living organisms: the key role of superoxide dismutase.

Authors:  B Halliwell
Journal:  Cell Biol Int Rep       Date:  1978-03

6.  Chemotactic deactivation of human neutrophils: possible relationship to stimulation of oxidative metabolism.

Authors:  R D Nelson; R T McCormack; V D Fiegel; M Herron; R L Simmons; P G Quie
Journal:  Infect Immun       Date:  1979-02       Impact factor: 3.441

7.  Synthetic peptide chemotactic factors for neutrophils: the range of active peptides, their efficacy and inhibitory activity, and susceptibility of the cellular response to enzymes and bacterial toxins.

Authors:  P C Wilkinson
Journal:  Immunology       Date:  1979-03       Impact factor: 7.397

8.  In vitro stimulation of neutrophil motility by levamisole: maintenance of cgmp levels in chemotactically stimulated levamisole-treated neutrophils.

Authors:  R Anderson; A Glover; H J Koornhof; A R Rabson
Journal:  J Immunol       Date:  1976-08       Impact factor: 5.422

9.  Leukocyte locomotion and chemotaxis. New methods for evaluation, and demonstration of a cell-derived chemotactic factor.

Authors:  S H Zigmond; J G Hirsch
Journal:  J Exp Med       Date:  1973-02-01       Impact factor: 14.307

10.  The deactivation of rabbit neutrophils by chemotactic factor and the nature of the activatable esterase.

Authors:  P A Ward; E L Becker
Journal:  J Exp Med       Date:  1968-04-01       Impact factor: 14.307
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