| Literature DB >> 7446317 |
Abstract
Hydroxyurea was administered intraperitoneally to pregnant albino rats in a single dose of 2000 mg/kg on day 14 of gestation. Both the perinatal and postnatal mortality rates of the progeny were increased and their weight gain reduced. Exploratory locomotion of 32-day-old rats, calculated by means of an 'activity index', was significantly reduced. The treatment had no effect on the brain weight. The fertility of the progeny was not impaired.Entities:
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Year: 1980 PMID： 7446317 DOI： 10.1007/bf01971445
Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299