Literature DB >> 7446166

Importance of spermatozoal zinc as temporary inhibitor of sperm nuclear chromatin decondensation ability in man.

U Kvist.   

Abstract

Nuclear chromatin decondensation (NCD) of ejaculated human spermatozoa was studied in vitro. Spermatozoa subjected to membrane disintegration induced by the detergent sodium dodecyl sulphate (SDS) were found to undergo NCD if previously or afterwards treated with substances known to deplete the spermatozoa of zinc (albumin and EDTA). Zn2+, but not other, "prostatic" cations (Ca2+, Mg2+), inhibited the experimentally induced NCD and the NCD of spermatozoa from men with impaired prostatic function. It is suggested that the human spermatozoon has an intrinsic mechanism for NCD, that is preserved by temporary zinc inhibition and might be reactivated by zinc removal within the female genital tract.

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Year:  1980        PMID： 7446166     DOI： 10.1111/j.1748-1716.1980.tb06567.x

Source DB:  PubMed          Journal:  Acta Physiol Scand        ISSN： 0001-6772


  13 in total

1.  Relationship between zinc concentrations in seminal plasma and various sperm parameters.

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Review 2.  Complete fertilization failure in ICSI.

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3.  Differential zinc and DNA binding by partial peptides of human protamine HP2.

Authors:  W Bal; M Dyba; Z Szewczuk; M Jezowska-Bojczuk; J Lukszo; G Ramakrishna; K S Kasprzak
Journal:  Mol Cell Biochem       Date:  2001-06       Impact factor: 3.396

4.  Events associated with restoration by zinc of meiosis in apomictic Saccharomyces cerevisiae.

Authors:  C A Bilinski; J J Miller; S C Girvitz
Journal:  J Bacteriol       Date:  1983-09       Impact factor: 3.490

5.  Isolation of sperm nuclei and nuclear matrices from the mouse, and other rodents.

Authors:  W Steven Ward
Journal:  Methods Mol Biol       Date:  2013

6.  Relationship between nuclear chromatin decondensation (NCD) in vitro and other sperm parameters and their predictive value on fertilization rate in IVF program.

Authors:  Mohamed E Hammadeh; Alexandra Bernardi; Theodosia Zeginiadou; Ahmed Amer; Werner Schmidt
Journal:  J Assist Reprod Genet       Date:  2005-08       Impact factor: 3.412

Review 7.  Spermatozoan Metabolism as a Non-Traditional Model for the Study of Huntington's Disease.

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Journal:  Int J Mol Sci       Date:  2022-06-28       Impact factor: 6.208

8.  In vitro effects of zinc, D-aspartic acid, and coenzyme-Q10 on sperm function.

Authors:  Filippo Giacone; Rosita A Condorelli; Laura M Mongioì; Valentina Bullara; Sandro La Vignera; Aldo E Calogero
Journal:  Endocrine       Date:  2016-07-15       Impact factor: 3.633

Review 9.  The present status of artificial oocyte activation in assisted reproductive technology.

Authors:  Kaoru Yanagida; Yoko Fujikura; Haruo Katayose
Journal:  Reprod Med Biol       Date:  2008-08-03

Review 10.  Zinc levels in seminal plasma and their correlation with male infertility: A systematic review and meta-analysis.

Authors:  Jiang Zhao; Xingyou Dong; Xiaoyan Hu; Zhou Long; Liang Wang; Qian Liu; Bishao Sun; Qingqing Wang; Qingjian Wu; Longkun Li
Journal:  Sci Rep       Date:  2016-03-02       Impact factor: 4.379
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