Culture of isolated glomeruli from normal and nephritic rabbits. II. Kinetics of outgrowing cells.

In the autologous phase of nephrotoxic nephritis in the rabbit, many round (Type III) cells appeared in the glomerular outgrowth. They had receptors for Fc and C3 and a pronounced phagocytic capacity for carbon. The number of Type III cells in the glomerular outgrowth from rabbits 8 days after injection of nephrotoxic serum (NTS-8) was higher than that of NTS-10 or -15. In contrast, they were rarely observed in the outgrowth of glomeruli from normal and NTS-3 rabbits. The Type II (fusiform) cell, a type of intrinsic glomerular cell, was also increased earlier and more markedly in NTS-8, -10, and -15 than in normal and NTS-3 rabbits.