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Literature DB >> 7442813

Evolutionary constraints in the mechanism of flavin catalysis.

Abstract

Analysis of the possible evolution of flavin catalysis in succinate dehydrogenase suggests as the ultimate state an active site that bears one or more acid functions and uses the enediol form of the substrate rather than the carbanion as a nucleophile. In the case of flavoenzyme catalyzed oxidation of fatty acylCoA, alpha-amino acids and alpha-hydroxy acids evolution to a similar mechanism seems to be blocked.

Entities: Chemical

Mesh：

Substances：

Year: 1980 PMID： 7442813 DOI： 10.1007/bf00450664

Source DB: PubMed Journal: Naturwissenschaften ISSN： 0028-1042

21 in total

1. Reconstitution of flavin enzymes with 1-carba-1 -deazaflavin coenzyme analogues.

Authors: R Spencer; J Fisher; C Walsh
Journal: Biochemistry Date: 1977-08-09 Impact factor: 3.162

2. Mechanistic features of the D-amino acid oxidase reaction studied by double stopped flow spectrophotometry.

Authors: D J Porter; J G Voet; H J Bright
Journal: J Biol Chem Date: 1977-07-10 Impact factor: 5.157

Review 3. Flavin and 5-deazaflavin: a chemical evaluation of 'modified' flavoproteins with respect to the mechanisms of redox biocatalysis.

Authors: P Hemmerich; V Massey
Journal: FEBS Lett Date: 1977-12-01 Impact factor: 4.124

10. Studies on the mechanism of action of the flavoenzyme lactate oxidase. Oxidation and elimination with beta-chlorolactate.

Authors: C Walsh; O Lockridge; V Massey; R Abeles
Journal: J Biol Chem Date: 1973-10-25 Impact factor: 5.157

1 in total

1. Evolutionary roots of catalysis by nicotinamide and flavins in C-H oxidoreductases and in photosynthesis.

Authors: C M Visser
Journal: Orig Life Date: 1982-06

1 in total

Evolutionary constraints in the mechanism of flavin catalysis.

1. Reconstitution of flavin enzymes with 1-carba-1 -deazaflavin coenzyme analogues.

2. Mechanistic features of the D-amino acid oxidase reaction studied by double stopped flow spectrophotometry.

Review 3. Flavin and 5-deazaflavin: a chemical evaluation of 'modified' flavoproteins with respect to the mechanisms of redox biocatalysis.

4. Mechanistic studies on the rat kidney flavoenzyme L-alpha-hydroxy acid oxidase.

5. Chemical achievement and hope for the future.

6. Stereochemical analysis of the elimination reaction catalyzed by D-amino-acid oxidase.

Review 7. Chemical approaches to the study of enzymes catalyzing redox transformations.

8. Studies on the mechanism of action of D-amino acid oxidase. Evidence for removal of substrate -hydrogen as a proton.

9. Mitochondrial monoamine oxidase. II. Action of various inhibitors for the bovine kidney enzyme. Catalytic mechanism.

10. Studies on the mechanism of action of the flavoenzyme lactate oxidase. Oxidation and elimination with beta-chlorolactate.

1. Evolutionary roots of catalysis by nicotinamide and flavins in C-H oxidoreductases and in photosynthesis.