Literature DB >> 7442470

Lecithin-cholesterol acyltransferase: inhibition by local anesthetics in plasma from man and experimental animals in vitro.

F P Bell, E V Hubert.   

Abstract

Lecithin-cholesterol acyltransferase (LCAT, EC 2.3.1.43) was assayed in vitro in plasma from normal man, rat, rabbit and dog by following the formation of 14C-cholesteryl esters subsequent to labeling the plasma with 14C-cholesterol in vitro. In all species examined, various local anesthetics were found to inhibit LCAT when studied over the concentration range of 1 to 5 mM. The order of inhibition was dibucaine>benzocaine>tetracaine>lidocaine>procaine. Since LCAT activity represents the combined effect of a deacylation step and an esterification step, inhibition of LCAT by local anesthetics could theoretically involve either or both steps.

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Year:  1980        PMID： 7442470     DOI： 10.1007/bf02534370

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  31 in total

1.  The esterification in vitro of free cholesterol in human and rat plasma.

Authors:  J A GLOMSET; F PARKER; M TJADEN; R H WILLIAMS
Journal:  Biochim Biophys Acta       Date:  1962-04-23

2.  Cholesterol exchange between microsomal, mitochondrial and erythrocyte membranes and its enhancement by cytosol.

Authors:  F P Bell
Journal:  Biochim Biophys Acta       Date:  1975-07-22

3.  Stimulation and inhibition of pancreatic phospholipase A2 by local anesthetics as a result of their interaction with the substrate.

Authors:  G Scherphof; H Westenberg
Journal:  Biochim Biophys Acta       Date:  1975-09-19

Review 4.  Anesthetic agents and cardiac electromechanical activity.

Authors:  M G Pratila; V Pratilas
Journal:  Anesthesiology       Date:  1978-11       Impact factor: 7.892

Review 5.  Studies on the mechanism of action of local anesthetics with phospholipid model membranes.

Authors:  D Papahadjopoulos
Journal:  Biochim Biophys Acta       Date:  1972-04-18

Review 6.  The metabolic role of lecithin: cholesterol acyltransferase: perspectives form pathology.

Authors:  J A Glomset; K R Norum
Journal:  Adv Lipid Res       Date:  1973

7.  Human plasma lecithin-cholesterol acyltransferase. Characterization of cofactor-dependent phospholipase activity.

Authors:  L Aron; S Jones; C J Fielding
Journal:  J Biol Chem       Date:  1978-10-25       Impact factor: 5.157

8.  Biosynthesis of various sterols, sterol esters, and squalene from [14C]mevalonate by normal swine intima and media in vitro: a comparative study.

Authors:  F P Bell
Journal:  Exp Mol Pathol       Date:  1976-12       Impact factor: 3.362

9.  Utilization of various sterols by lecithin-cholesterol acyltransferase as acyl acceptors.

Authors:  U Piran; T Nishida
Journal:  Lipids       Date:  1979-05       Impact factor: 1.880

10.  The action of local anaesthetics on lipolysis and on adenosine 3':5'-cyclic monophosphate content in isolated rat fat-cells.

Authors:  K Siddle; C N Hales
Journal:  Biochem J       Date:  1974-08       Impact factor: 3.857
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  1 in total

1.  Inhibition of LCAT in plasma from man and experimental animals by chlorpromazine.

Authors:  F P Bell; E V Hubert
Journal:  Lipids       Date:  1981-11       Impact factor: 1.880
  1 in total

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