Literature DB >> 7442328

Loss of gene repression activity: a theory of cellular senescence.

J R Smith, C K Lumpkin.   

Abstract

Recent evidence bearing on cellular senescence has come from cell fusion and clonal lifespan studies. To date, no model has been developed that is consistent with the recent findings. The purpose of this paper is to present a mechanism for cell senescence that is qualitatively consistent with the experimental evidence.

Mesh：

Year:  1980        PMID： 7442328     DOI： 10.1016/0047-6374(80)90080-9

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN： 0047-6374            Impact factor:   5.432


  3 in total

1.  Genetic analysis of indefinite division in human cells: identification of four complementation groups.

Authors:  O M Pereira-Smith; J R Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205

2.  A genetic model for age at onset in Huntington disease.

Authors:  L A Farrer; P M Conneally
Journal:  Am J Hum Genet       Date:  1985-03       Impact factor: 11.025

3.  Evidence for endogenous polypeptide-mediated inhibition of cell-cycle transit in human diploid cells.

Authors:  G C Burmer; C J Zeigler; T H Norwood
Journal:  J Cell Biol       Date:  1982-07       Impact factor: 10.539
  3 in total

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