Literature DB >> 744100

Down regulation of insulin receptors in primary cultures of adult rat hepatocytes in monolayer.

W G Blackard, P S Guzelian, M E Small.   

Abstract

Down regulation of insulin receptor number by insulin at physiological concentrating (10(-9) M) has been demonstrated in primary cultures of adult rat liver parenchymal cells in monolayer. However, because insulin is rapidly degraded in this culture system, special efforts are necessary to maintain the concentration of insulin in the medium in order to evoke the down regulation phenomenon.

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Year:  1978        PMID： 744100     DOI： 10.1210/endo-103-2-548

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  37 in total

1.  Down regulation of insulin receptors.

Authors:  W G Blackard; P S Guzelian; E E Small
Journal:  Trans Am Clin Climatol Assoc       Date:  1979

2.  Pathogenesis of selective insulin resistance in isolated hepatocytes.

Authors:  Joshua R Cook; Fanny Langlet; Yoshiaki Kido; Domenico Accili
Journal:  J Biol Chem       Date:  2015-04-14       Impact factor: 5.157

3.  Insulin binding to isolated hepatocytes of Atlantic salmon and rainbow trout.

Authors:  E M Plisetskaya; E Fabbri; T W Moon; J Gutiérrez; C Ottolenghi
Journal:  Fish Physiol Biochem       Date:  1993-07       Impact factor: 2.794

4.  Analysis of interaction between insulin binding and insulin effect on primary culture of normal and db/db mouse hepatocytes.

Authors:  T Ueno; S Ozaki
Journal:  Gastroenterol Jpn       Date:  1990-06

5.  Desensitization of the insulin receptor by antireceptor antibodies in vivo is blocked by treatment of mice with beta-adrenergic agonists.

Authors:  D Elias; M Rapoport; I R Cohen; Y Shechter
Journal:  J Clin Invest       Date:  1988-06       Impact factor: 14.808

6.  Glucocorticoid-induced insulin resistance: the importance of postbinding events in the regulation of insulin binding, action, and degradation in freshly isolated and primary cultures of rat hepatocytes.

Authors:  J F Caro; J M Amatruda
Journal:  J Clin Invest       Date:  1982-04       Impact factor: 14.808

7.  Analysis of insulin receptors on human lymphoblastoid cell lines by flow cytometry.

Authors:  R Maron; S I Taylor; R Jackson; C R Kahn
Journal:  Diabetologia       Date:  1984-07       Impact factor: 10.122

8.  Infusion of insulin impairs human adipocyte glucose metabolism in vitro without decreasing adipocyte insulin receptor binding.

Authors:  L Mandarino; B Baker; R Rizza; J Genest; J Gerich
Journal:  Diabetologia       Date:  1984-09       Impact factor: 10.122

9.  Insulin-receptor binding in skeletal muscle of trout.

Authors:  J Gutiérrez; T Asgård; E Fabbri; E M Plisetskaya
Journal:  Fish Physiol Biochem       Date:  1991-12       Impact factor: 2.794

10.  Loss of insulin-induced inhibition of glucagon gene transcription in hamster pancreatic islet alpha cells by long-term insulin exposure.

Authors:  M González; U Böer; C Dickel; T Quentin; I Cierny; E Oetjen; W Knepel
Journal:  Diabetologia       Date:  2008-09-02       Impact factor: 10.122
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