Literature DB >> 7440428

Kanamycin ototoxicity and pigmentation in the guinea pig.

S D Comis, G Leng.   

Abstract

Cochleas from albino and pigmented guinea pigs were examined histologically following chronic administration of Kanamycin. In pigmented animals, damage was concentrated amongst hair cells towards the base, but in albinos, hair cell damage was diffusely spread. These observations support suggestions that melanin is implicated in Kanamycin ototoxicity.

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Year:  1980        PMID： 7440428     DOI： 10.1016/0378-5955(80)90051-9

Source DB:  PubMed          Journal:  Hear Res        ISSN： 0378-5955            Impact factor:   3.208


  4 in total

1.  [Cisplatin-induced hearing loss in children in relation to eye color].

Authors:  H C Martin; C M Schmidt; H J Boos; A Heinecke; A G Dinnesen
Journal:  HNO       Date:  2007-06       Impact factor: 1.284

2.  Melanin in the inner ear. An experimental study with control and kanamycin-intoxicated colored guinea-pigs.

Authors:  B Gratacap; A Attard; A Laurent; P Stoebner; D Smirou; R Charachon
Journal:  Arch Otorhinolaryngol       Date:  1989

3.  Some otological differences between pigmented and albino-type guinea pigs.

Authors:  R V Harrison; A Palmer; J M Aran
Journal:  Arch Otorhinolaryngol       Date:  1984

4.  Comparative oto-vestibular effects in the pigmented guinea pig after dibekacin and netilmicin treatment.

Authors:  F Bamonte; G Melone; A Monopoli; E Ongini; A Forlani
Journal:  Arch Otorhinolaryngol       Date:  1986
  4 in total

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