Literature DB >> 7440256

Histofluorescence technique for the intracellular localization of chemical carcinogens.

C Stora.   

Abstract

Many carcinogens exhibit a fluorescent emission when excited with ultraviolet light. Advantage has been taken of this property to develop a technique that can detect microquantities of these carcinogens on conventional microscopic tissue preparations. This work describes the localization of aflatoxin B1, N-2-fluorenylacetamide and benzo(a)pyrene both in the cell cytoplasm and nucleus after in vivo administration of these compounds.

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Year:  1980        PMID： 7440256     DOI： 10.1007/bf01012018

Source DB:  PubMed          Journal:  Histochem J        ISSN： 0018-2214


  16 in total

1.  UPTAKE OF HYDROCARBON CARCINOGENS BY LYSOSOMES.

Authors:  A C ALLISON; L MALLUCCI
Journal:  Nature       Date:  1964-09-05       Impact factor: 49.962

2.  2,3-Dihydro-2-(guan-7-yl)-3-hydroxy-aflatoxin B1, a major acid hydrolysis product of aflatoxin B1-DNA or -ribosomal RNA adducts formed in hepatic microsome-mediated reactions and in rat liver in vivo.

Authors:  J K Lin; J A Miller; E C Miller
Journal:  Cancer Res       Date:  1977-12       Impact factor: 12.701

3.  Covalent intercalative binding to DNA in relation to the mutagenicity of hydrocarbon epoxides and N-acetoxy-2-acetylaminofluorene.

Authors:  N R Drinkwater; J A Miller; E C Miller; N C Yang
Journal:  Cancer Res       Date:  1978-10       Impact factor: 12.701

4.  A fluorescence microscopic study of methodologic effects on the intranuclear distribution of benzo(alpha)pyrene.

Authors:  T K Shires
Journal:  Cancer Res       Date:  1969-06       Impact factor: 12.701

5.  Modifications of ribonucleic acid by chemical carcinogens. II. In vivo reaction of N-2-acetylaminofluorene with rat liver ribonucleic acid.

Authors:  M K Agarwal; I B Weinstein
Journal:  Biochemistry       Date:  1970-02-03       Impact factor: 3.162

6.  Cellular localization of chemical carcinogens studied by fluorescence microscopy.

Authors:  C Stora
Journal:  Oncology       Date:  1980       Impact factor: 2.935

7.  [Radioautographic studies on the cytological distribution of the cancerogenic hydrocarbon 9,10-dimethyl-1,2-benzanthracene (DMBA)].

Authors:  E Amlacher; A Graffi
Journal:  Arch Geschwulstforsch       Date:  1966

8.  Quantitative aspects of the reaction of some carcinogens with nucleic acids and the possible significance of such reactions in the process of carcinogenesis.

Authors:  P Brookes
Journal:  Cancer Res       Date:  1966-09       Impact factor: 12.701

9.  Hepatocarcinogenesis by aflatoxin B1: relationships between the cellular localization of the carcinogen and early histological changes in the rat liver.

Authors:  C Stora; C Aussel; O Mayzaud; R Masseyeff
Journal:  Biomedicine       Date:  1979-10

10.  The distribution of polycyclic hydrocarbons within the cells of some mouse and rat tissues.

Authors:  G CALCUTT
Journal:  Br J Cancer       Date:  1958-03       Impact factor: 7.640
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