Literature DB >> 7440046

Do sunlight and vitamin D reduce the likelihood of colon cancer?

C F Garland, F C Garland.   

Abstract

It is proposed that vitamin D is a protective factor against colon cancer. This hypothesis arose from inspection of the geographic distribution of colon cancer deaths in the U.S., which revealed that colon cancer mortality rates were highest in places where populations were exposed to the least amounts of natural light--major cities, and rural areas in high latitudes. The hypothesis is supported by a comparison of colon cancer mortality rates in areas that vary in mean daily solar radiation penetrating the atmosphere. A mechanism involving cholecalciferol (vitamin D3) is suggested. The possibility that an ecological fallacy or other indirect association explains the findings is explored.

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Year:  1980        PMID: 7440046     DOI: 10.1093/ije/9.3.227

Source DB:  PubMed          Journal:  Int J Epidemiol        ISSN: 0300-5771            Impact factor:   7.196


  199 in total

1.  Sunlight and health. Use of sunscreens does not risk vitamin D deficiency.

Authors:  R Marks
Journal:  BMJ       Date:  1999-10-16

Review 2.  Vitamin D and Gastrointestinal Cancers: A Narrative Review.

Authors:  Hemant Goyal; Abhilash Perisetti; M Rubayat Rahman; Avi Levin; Giuseppe Lippi
Journal:  Dig Dis Sci       Date:  2018-12-03       Impact factor: 3.199

Review 3.  Vitamin D and cancer: a review of molecular mechanisms.

Authors:  James C Fleet; Marsha DeSmet; Robert Johnson; Yan Li
Journal:  Biochem J       Date:  2012-01-01       Impact factor: 3.857

4.  More on preventing skin cancer: sun avoidance will increase incidence of cancers overall.

Authors:  Cedric F Garland
Journal:  BMJ       Date:  2003-11-22

5.  Blood 25-hydroxyvitamin D3 concentrations and incident sporadic colorectal adenoma risk: a pooled case-control study.

Authors:  Veronika Fedirko; Roberd M Bostick; Michael Goodman; W Dana Flanders; Myron D Gross
Journal:  Am J Epidemiol       Date:  2010-07-22       Impact factor: 4.897

Review 6.  Role of vitamins in gastrointestinal diseases.

Authors:  Omar A Masri; Jean M Chalhoub; Ala I Sharara
Journal:  World J Gastroenterol       Date:  2015-05-07       Impact factor: 5.742

7.  Regulation of VDR Expression in Apc-Mutant Mice, Human Colon Cancers and Adenomas.

Authors:  Charles Giardina; Masako Nakanishi; Awaad Khan; Anton Kuratnik; Wanli Xu; Bruce Brenner; Daniel W Rosenberg
Journal:  Cancer Prev Res (Phila)       Date:  2015-04-14

Review 8.  Vitamin D3 from Ultraviolet-B Exposure or Oral Intake in Relation to Cancer Incidence and Mortality.

Authors:  William B Grant; Meis Moukayed
Journal:  Curr Nutr Rep       Date:  2019-09

9.  Chemoprevention for colorectal neoplasia.

Authors:  Alyssa D Fajardo; Bruce W Robb
Journal:  Clin Colon Rectal Surg       Date:  2008-11

10.  Solar UV radiation and cancer in young children.

Authors:  Christina Lombardi; Julia E Heck; Myles Cockburn; Beate Ritz
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2013-04-12       Impact factor: 4.254

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