Literature DB >> 7439686

Nucleotide sequences of class-switch recombination region of the mouse immunoglobulin gamma 2b-chain gene.

N Takahashi, T Kataoka, T Honjo.   

Abstract

We have cloned a rearranged gamma 2b-chain gene from mouse myeloma MOPC141. Nucleotide-sequence determination demonstrated that the rearranged gamma 2b-chain gene was formed by a recombination between the region flanking the 5'-ends of the embryonic mu-chain gene and that of the gamma 2b-chain genes. Nucleotide sequences similar to the one located adjacent to the recombination site were found in other parts of the region flanking the 5'-end of the mu-chain-gene, as well as in the region flanking the 5'-end of the gamma 1-chain gene. The common sequence (GGTANNAAAGNAC) shares extensive homology with the sequence proximal to the insertion site of the bacterial insertion element IS2.

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Year:  1980        PMID： 7439686     DOI： 10.1016/0378-1119(80)90092-x

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  20 in total

1.  Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination.

Authors:  X Chen; K Kinoshita; T Honjo
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-20       Impact factor: 11.205

2.  Isolation of differentially expressed genes upon immunoglobulin class switching by a subtractive hybridization method using uracil DNA glycosylase.

Authors:  M Sugai; S Kondo; A Shimizu; T Honjo
Journal:  Nucleic Acids Res       Date:  1998-02-15       Impact factor: 16.971

3.  A measure of the similarity of sets of sequences not requiring sequence alignment.

Authors:  B E Blaisdell
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

4.  Looping out and deletion mechanism for the immunoglobulin heavy-chain class switch.

Authors:  H M Jäck; M McDowell; C M Steinberg; M Wabl
Journal:  Proc Natl Acad Sci U S A       Date:  1988-03       Impact factor: 11.205

5.  On immunoglobulin heavy chain gene switching: two gamma 2b genes are rearranged via switch sequences in MPC-11 cells but only one is expressed.

Authors:  R B Lang; L W Stanton; K B Marcu
Journal:  Nucleic Acids Res       Date:  1982-01-22       Impact factor: 16.971

6.  Cloning of human immunoglobulin epsilon chain genes: evidence for multiple C epsilon genes.

Authors:  Y Nishida; T Miki; H Hisajima; T Honjo
Journal:  Proc Natl Acad Sci U S A       Date:  1982-06       Impact factor: 11.205

7.  Structure of a rearranged gamma 1 chain gene and its implication to immunoglobulin class-switch mechanism.

Authors:  M Obata; T Kataoka; S Nakai; H Yamagishi; N Takahashi; Y Yamawaki-Kataoka; T Nikaido; A Shimizu; T Honjo
Journal:  Proc Natl Acad Sci U S A       Date:  1981-04       Impact factor: 11.205

8.  Choice of base at silent codon site 3 is not selectively neutral in eucaryotic structural genes: it maintains excess short runs of weak and strong hydrogen bonding bases.

Authors:  B E Blaisdell
Journal:  J Mol Evol       Date:  1983       Impact factor: 2.395

9.  Nonhomologous recombination at sites within the mouse JH-C delta locus accompanies C mu deletion and switch to immunoglobulin D secretion.

Authors:  J D Owens; F D Finkelman; J D Mountz; J F Mushinski
Journal:  Mol Cell Biol       Date:  1991-11       Impact factor: 4.272

10.  Immunoglobulin switch region-like sequences in Drosophila melanogaster.

Authors:  Y Sakoyama; Y Yaoita; T Honjo
Journal:  Nucleic Acids Res       Date:  1982-07-24       Impact factor: 16.971
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