Literature DB >> 7439339

Effect of splanchnectomy and vagotomy on the pepsinogen response to intragastric acid.

D E Webber, S M Morrissey.   

Abstract

Perfusion of the stomach in the anaesthetized rat with saline acidified to pH 2.5 with hydrochloric acid induced a small but significant release of pepsinogen into the perfusate. This stimulus to secretion was unaffected by splanchnectomy but was abolished by vagotomy. It is concluded that a modest degree acid secretion in the rat may stimulate pepsinogen secretion by a vagal pathway.

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Year:  1980        PMID: 7439339     DOI: 10.1007/bf01953838

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  13 in total

1.  Laboratory criteria for the completeness of vagotomy.

Authors:  W H BACHRACH
Journal:  Am J Dig Dis       Date:  1962-12

2.  Continuous recording of acid gastric secretion in the rat.

Authors:  M N GHOSH; H O SCHILD
Journal:  Br J Pharmacol Chemother       Date:  1958-03

3.  Regulation of pepsin secretion by topical acid in the stomach.

Authors:  L R Johnson
Journal:  Am J Physiol       Date:  1972-10

Review 4.  Pepsin.

Authors:  D F Magee
Journal:  Med Clin North Am       Date:  1974-11       Impact factor: 5.456

5.  Separate hypoglycaemic thresholds for gastric acid and pepsin secretion following insulin or posterior hypothalamic stimulation.

Authors:  D E Webber; S M Morrissey
Journal:  Can J Physiol Pharmacol       Date:  1979-11       Impact factor: 2.273

6.  Stimulation of human pepsin output by tropical hydrochloric acid.

Authors:  T E Bynum; L R Johnson
Journal:  Am J Dig Dis       Date:  1975-07

7.  Vagal stimulation of gastric secretion in man by 2-deoxy-D-glucose.

Authors:  W W Duke; B I Hirschowitz; G Sachs
Journal:  Lancet       Date:  1965-10-30       Impact factor: 79.321

8.  Gastric emptying and secretion in the calf on duodenal infusion of tryptophan, tryptamine and 5-hydroxytryptamine.

Authors:  F R Bell; D E Webber
Journal:  J Physiol       Date:  1979-06       Impact factor: 5.182

9.  Effect of intragastric acid on pepsinogen secretion in the rat.

Authors:  J Puurunen
Journal:  Eur J Pharmacol       Date:  1979-04-15       Impact factor: 4.432

10.  THE ESTIMATION OF PEPSIN, TRYPSIN, PAPAIN, AND CATHEPSIN WITH HEMOGLOBIN.

Authors:  M L Anson
Journal:  J Gen Physiol       Date:  1938-09-20       Impact factor: 4.086

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