Literature DB >> 7439261

Monoamine metabolites in cerebrospinal fluid during treatment of hypertension with prazosin.

P Seideman, L Bertilsson, K Haglund, F Sjöqvist, G Tybring, J Ostman.   

Abstract

Six hypertensive patients were treated with prazosin up to a final dose of 3-4.5 mg/day. There was a significant reduction of blood pressure. The cerebrospinal fluid (CSF) concentrations of the major metabolites of noradrenaline, dopamine and serotonin were unchanged. This indicates that the antihypertensive effect is not mediated via central monoaminergic neurons as suggested by animal studies.

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Year:  1980        PMID： 7439261     DOI： 10.1007/bf00636792

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  9 in total

1.  R 28935 and prazosin: effects on central and peripheral alpha-adrenoreceptor activity and on blood pressure.

Authors:  N E Andén; C Gomes; B Persson; G Trolin
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-05       Impact factor: 3.000

2.  Comparative studies on central factors contributing to the hypotensive action of propranolol, alprenolol, and their enantiomers.

Authors:  L Offerhaus; P A van Zwieten
Journal:  Cardiovasc Res       Date:  1974-07       Impact factor: 10.787

3.  Gas chromatographic determination of homovanillic acid in human cerebrospinal fluid by electron capture detection and by mass fragmentography with a deuterated internal standard.

Authors:  B Sjöquist; E Anggård
Journal:  Anal Chem       Date:  1972-12       Impact factor: 6.986

4.  Quantitative determination of 4-hydroxy-3-methoxyphenyl glycol and its conjugates in cerebrospinal fluid by mass fragmentography.

Authors:  L Bertilsson
Journal:  J Chromatogr       Date:  1973-12-05

5.  Quantitative determination of 5-hydroxyindole-3-acetic acid in cerebrospinal fluid by gas chromatography-mass spectrometry.

Authors:  L Bertilsson; A J Atkinson; J R Althaus; A Härfast; J E Lindgren; B Holmstedt
Journal:  Anal Chem       Date:  1972-07       Impact factor: 6.986

Review 6.  The central action of antihypertensive drugs, mediated via central alpha-receptors.

Authors:  P A van Zwieten
Journal:  J Pharm Pharmacol       Date:  1973-02       Impact factor: 3.765

7.  Central adrenoreceptors and the control of arterial blood pressure.

Authors:  M D Day; A G Roach
Journal:  Clin Exp Pharmacol Physiol       Date:  1974 Jul-Aug       Impact factor: 2.557

8.  Effect of prazosin on blood pressure and plasma renin activity in man.

Authors:  J Rosenthal; H Jaeger; I Arlart
Journal:  Clin Sci Mol Med Suppl       Date:  1978-12

9.  Monoamine metabolites in cerebrospinal fluid during treatment with clonidine or alprenolol.

Authors:  L Bertilsson; K Haglund; J Ostman; M D Rawlins; V A Ringberger; F Sjöqvist
Journal:  Eur J Clin Pharmacol       Date:  1977-01-03       Impact factor: 2.953
  9 in total
  1 in total

Review 1.  Prazosin update. A review of its pharmacological properties and therapeutic use in hypertension and congestive heart failure.

Authors:  W F Stanaszek; D Kellerman; R N Brogden; J A Romankiewicz
Journal:  Drugs       Date:  1983-04       Impact factor: 9.546
  1 in total

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