Literature DB >> 7438547

IgE-dependent adherence and cytotoxicity of rat spleen and peritoneal cells to Litomosoides carinii microfilariae.

K Mehta, R K Sindhu, D Subrahmanyam, D S Nelson.   

Abstract

Serum taken after the termination of microfilaraemia from rats infected with the filarial parasite Litomosoides carinii brought about adherence and cytotoxicity of normal rat spleen and peritoneal cells to microfilariae. The activity could be absorbed to, and eluted from, anti-rat IgE, but not anti-rat IgG, immunosorbent columns. Immune serum heated to 56 degrees C for 3 hr did not cause cellular adherence or cytotoxicity; the addition of fresh normal rat serum failed to restore activity. Fresh rat serum did, however, restore activity to immune serum which was inactive after being heated to 56 degrees C for 30 min. EDTA, EGTA and diethylcarbamazine inhibited adherence. It is concluded that IgE antibodies are responsible for cellular adherence and cytotoxicity and that complement may play a part, as yet undefined, in these reactions.

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Year:  1980        PMID： 7438547      PMCID： PMC1536934     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  29 in total

1.  Combined in vitro effects of rat antibody and neutrophilic leukocytes on schistosomula of Schistosoma mansoni.

Authors:  D A Dean; R Wistar; K D Murrell
Journal:  Am J Trop Med Hyg       Date:  1974-05       Impact factor: 2.345

2.  Characteristics of complement fixation by aggregated IgE.

Authors:  T Ishizaka; C S Soto; K Ishizaka
Journal:  J Immunol       Date:  1972-12       Impact factor: 5.422

3.  Interactions of antibodies and effector cells in immunity against tumours.

Authors:  A C Allison
Journal:  Ann Inst Pasteur (Paris)       Date:  1972-04

4.  Immunochemical studies with filarial antigens.

Authors:  R C Bagai; D Subrahmanyam; V B Singh
Journal:  Indian J Med Res       Date:  1968-07       Impact factor: 2.375

5.  Nature of acquired resistance to filarial infection in albino rats.

Authors:  R C Bagai; D Subrahmanyam
Journal:  Nature       Date:  1970-11-14       Impact factor: 49.962

6.  Studies on the host-parasite relation in albino rats infected with Litomosoides carinii.

Authors:  R C Bagai; D Subrahmanyam
Journal:  Am J Trop Med Hyg       Date:  1968-11       Impact factor: 2.345

7.  Evidence for the role of antibody in the cytotoxic action of lymph cells on xenogeneic target cells.

Authors:  C K Grant; P J Avis; J G Hall; P Alexander
Journal:  Transplantation       Date:  1971-03       Impact factor: 4.939

8.  C3 shunt activation in human serum chelated with EGTA.

Authors:  D P Fine; S R Marney; D G Colley; J S Sergent; R M Des Prez
Journal:  J Immunol       Date:  1972-10       Impact factor: 5.422

9.  In vitro adhesion of eosinophils to infective larvae of Wuchereria bancrofti.

Authors:  G I Higashi; A B Chowdhury
Journal:  Immunology       Date:  1970-07       Impact factor: 7.397

10.  Chemical coupling of peptides and proteins to polysaccharides by means of cyanogen halides.

Authors:  R Axén; J Porath; S Ernback
Journal:  Nature       Date:  1967-06-24       Impact factor: 49.962
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  16 in total

Review 1.  IgE and immune defense mechanism.

Authors:  J P Dessaint; A Capron
Journal:  Clin Rev Allergy       Date:  1989

Review 2.  A comprehensive, model-based review of vaccine and repeat infection trials for filariasis.

Authors:  C Paul Morris; Holly Evans; Sasha E Larsen; Edward Mitre
Journal:  Clin Microbiol Rev       Date:  2013-07       Impact factor: 26.132

Review 3.  Fc epsilon receptor II-positive macrophages and platelets: potent effector cells in allergy and defence against helminth parasites.

Authors:  J P Dessaint; A Capron
Journal:  Springer Semin Immunopathol       Date:  1990

4.  IgG response of rats to the excretory-secretory products of Litomosoides carinii.

Authors:  R Chandrashekar; U R Rao; D Subrahmanyam
Journal:  Parasitol Res       Date:  1990       Impact factor: 2.289

5.  Effect of liposomal amphotericin B on murine macrophages and lymphocytes.

Authors:  R T Mehta; K Mehta; G Lopez-Berestein; R L Juliano
Journal:  Infect Immun       Date:  1985-02       Impact factor: 3.441

6.  The ability of microfilariae to evade in vitro cell-mediated cytotoxicity.

Authors:  C M Rzepczyk; C J Bishop; R B Atwell
Journal:  Z Parasitenkd       Date:  1986

7.  IgE-dependent cellular adhesion and cytotoxicity to Litomosoides carinii microfilariae--nature of effector cells.

Authors:  K Mehta; R K Sindhu; D Subrahmanyam; K Hopper; D S Nelson
Journal:  Clin Exp Immunol       Date:  1982-05       Impact factor: 4.330

Review 8.  Nematodes and the spleen: an immunological relationship.

Authors:  J L John
Journal:  Experientia       Date:  1994-01-15

9.  Increased expression of the IgE Fc receptors on rat macrophages induced by elevated serum IgE levels.

Authors:  G Boltz-Nitulescu; J M Plummer; H L Spiegelberg
Journal:  Immunology       Date:  1984-09       Impact factor: 7.397

10.  Immunity to Litomosoides carinii in Mastomys natalensis. II. Effects of chemotherapeutically abbreviated and postpatent primary infections on challenges with various stages of the parasite.

Authors:  H Zahner; P H Wegerhof
Journal:  Z Parasitenkd       Date:  1986
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