Literature DB >> 7437912

Aging process affects a single class of dopamine receptors.

M Memo, L Lucchi, P F Spano, M Trabucchi.   

Abstract

[3H]Spiroperidol and [3H](-)-sulpiride specific binding have been used to assay for D1 and D2 dopaminergic recognition sites in striatal membranes of aged rats. While [3H]spiroperidol binding shows a decreased number of binding sites, no changes have been detected in [3H](-)-sulpiride binding, which is a marker for D2 dopaminergic receptors. Data obtained with GTP and DA-dependent adenylyl cyclase activity confirm the hypothesis that aging selectively affects in rats those dopaminergic receptors coupled to the formation of cyclic AMP (D1).

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Year:  1980        PMID： 7437912     DOI： 10.1016/0006-8993(80)90161-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  6 in total

1.  Dysregulation of Striatal Dopamine Receptor Binding in Suicide.

Authors:  Megan L Fitzgerald; Suham A Kassir; Mark D Underwood; Mihran J Bakalian; J John Mann; Victoria Arango
Journal:  Neuropsychopharmacology       Date:  2016-07-12       Impact factor: 7.853

2.  Quantification of small molecule drugs in biological tissue sections by imaging mass spectrometry using surrogate tissue-based calibration standards.

Authors:  Nozomi Takai; Yukari Tanaka; Hideo Saji
Journal:  Mass Spectrom (Tokyo)       Date:  2014-02-01

3.  Impact of wheel running on chronic ethanol intake in aged Syrian hamsters.

Authors:  Allison J Brager; Steven B Hammer
Journal:  Physiol Behav       Date:  2012-09-25

4.  Diminished viability, growth, and behavioral efficacy of fetal dopamine neuron grafts in aging rats with long-term dopamine depletion: an argument for neurotrophic supplementation.

Authors:  T J Collier; C E Sortwell; B F Daley
Journal:  J Neurosci       Date:  1999-07-01       Impact factor: 6.167

5.  Age influences magnitude but not duration of response to levodopa.

Authors:  R Durso; K Isaac; L Perry; M Saint-Hilaire; R G Feldman
Journal:  J Neurol Neurosurg Psychiatry       Date:  1993-01       Impact factor: 10.154

6.  Autoradiographic analysis of regional alterations in brain receptors following chronic administration and withdrawal of typical and atypical neuroleptics in rats.

Authors:  R E See; A W Toga; G Ellison
Journal:  J Neural Transm Gen Sect       Date:  1990
  6 in total

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