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Literature DB >> 7436487

Homozygous deficiency of the second component of complement presenting with recurrent bacterial meningitis.

Y H Thong, D A Simpson, H J Müller-Eberhard.

Abstract

A girl presented with purulent meningitis at ages 6, 8, and 11 years. She was in good health between these three episodes. When aged 16 one of her brothers also experienced an attack of pneumococcal meningitis. Complement studies showed lack of C2 in the patient and the brother, and intermediate values in the mother and a sister. No other member of the family was available for study.

Entities: Disease Species

Mesh：

Substances：
Complement C2

Year: 1980 PMID： 7436487 PMCID： PMC1626939 DOI： 10.1136/adc.55.6.471

Source DB: PubMed Journal: Arch Dis Child ISSN： 0003-9888 Impact factor: 3.791

13 in total

Review 1. Complement.

Authors: H J Müller-Eberhard
Journal: Annu Rev Biochem Date: 1975 Impact factor: 23.643

2. Complement and host defense against infection.

Authors: R B Johnston; R M Stroud
Journal: J Pediatr Date: 1977-02 Impact factor: 4.406

3. F(ab')2 reagents are not required if goat, rather than rabbit, antibodies are used to detect human surface immunoglobulin.

Authors: E L Alexander; S K Sanders
Journal: J Immunol Date: 1977-09 Impact factor: 5.422

4. Traumatic cerebrospinal fluid fistulas in children.

Authors: W J Caldicott; J B North; D A Simpson
Journal: J Neurosurg Date: 1973-01 Impact factor: 5.115

5. A semi-automated microassay technique for quantitative leukocyte iodination.

Authors: Y H Thong; A Ferrante
Journal: J Immunol Methods Date: 1978 Impact factor: 2.303

6. Recurrent septicemia associated with congenital deficiency of C2 and partial deficiency of factor B and the alternative complement pathway.

Authors: S L Newman; L B Vogler; R D Feigin; R B Johnston
Journal: N Engl J Med Date: 1978-08-10 Impact factor: 91.245

7. Abnormal neutrophil chemotaxis in a syndrome of unusual facies, proportionate small stature and sensorineural deafness-mutism.

Authors: Y H Thong; B S Douglas; A Ferrante
Journal: Acta Paediatr Scand Date: 1978-05

8. Neutrophil phagocytic and bactericidal dysfunction induced by bilirubin.

Authors: Y H Thong; A Ferrante; D Ness
Journal: Aust Paediatr J Date: 1977-12

9. Influenza: response of T-cell lymphopenia to thymosin.

Authors: M Scheinberg; N R Blacklow; A L Goldstein; T A Parrino; F B Rose; E S Cathcart
Journal: N Engl J Med Date: 1976-05-27 Impact factor: 91.245

10. C2 deficiency. Development of lupus erythematosus.

Authors: N K Day; H Geiger; R McLean; A Michael; R A Good
Journal: J Clin Invest Date: 1973-07 Impact factor: 14.808

15 in total

Review 1. Recurrent meningitis: a case report.

Authors: M Ceccarelli; M Balestri; C Fontani; L Lupetti; C Ughi
Journal: Eur J Pediatr Date: 1989-06 Impact factor: 3.183

Review 2. The genetic basis of pneumococcal and staphylococcal infections: inborn errors of human TLR and IL-1R immunity.

Authors: Bertrand Boisson
Journal: Hum Genet Date: 2020-01-24 Impact factor: 4.132

Homozygous deficiency of the second component of complement presenting with recurrent bacterial meningitis.

Review 1. Complement.

2. Complement and host defense against infection.

3. F(ab')2 reagents are not required if goat, rather than rabbit, antibodies are used to detect human surface immunoglobulin.

4. Traumatic cerebrospinal fluid fistulas in children.

5. A semi-automated microassay technique for quantitative leukocyte iodination.

6. Recurrent septicemia associated with congenital deficiency of C2 and partial deficiency of factor B and the alternative complement pathway.

7. Abnormal neutrophil chemotaxis in a syndrome of unusual facies, proportionate small stature and sensorineural deafness-mutism.

8. Neutrophil phagocytic and bactericidal dysfunction induced by bilirubin.

9. Influenza: response of T-cell lymphopenia to thymosin.

10. C2 deficiency. Development of lupus erythematosus.

Review 1. Recurrent meningitis: a case report.

Review 2. The genetic basis of pneumococcal and staphylococcal infections: inborn errors of human TLR and IL-1R immunity.

Review 3. Lupus diseases associated with hereditary and acquired deficiencies of complement.

Review 4. Inherited deficiencies of complement proteins in man.

5. Activation of human complement by the pneumococcal toxin pneumolysin.

6. Differential complement resistance mediates virulence of Haemophilus influenzae type b.

Review 7. Infectious diseases associated with complement deficiencies.

8. Activation of the alternative pathway of complement by Acanthamoeba culbertsoni.

9. Immunological competence of children with pyogenic meningitis.

10. Recurrent pyogenic infections in individuals with absence of the second component of complement.