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Literature DB >> 743629

Ranking of excitatory amino acids by the antagonists glutamic acid diethylester and D-alpha-aminoadipic acid.

Abstract

A separation of the excitatory actions of the amino acids upon thalamic neurones of rats anaesthetized with urethane has been accomplished through the use of two antagonists. It has been possible to rank the excitatory compounds in their order of susceptibility to D-alpha-aminoadipic acid (DalphaAA) and L-glutamic acid diethylester (GDEE). The observation that the ranking orders of the excitants differ for these two antagonists permits an analysis of the types of receptors with which the amino acid excitants react. The results support the proposition that more than one neuronal receptor sensitive to the amino acids exists.

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Year: 1978 PMID： 743629 DOI： 10.1139/y78-143

Source DB: PubMed Journal: Can J Physiol Pharmacol ISSN： 0008-4212 Impact factor: 2.273

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Cited

10 in total

1. A comparison between the in vivo and in vitro activity of five potent and competitive NMDA antagonists.

Authors: D Lodge; S N Davies; M G Jones; J Millar; D T Manallack; P L Ornstein; A J Verberne; N Young; P M Beart
Journal: Br J Pharmacol Date: 1988-11 Impact factor: 8.739

2. Inhibition of quisqualate-induced seizures by glutamic acid diethyl ester and anti-epileptic drugs.

Authors: S S Schwarz; W J Freed
Journal: J Neural Transm Date: 1986 Impact factor: 3.575

3. The action of six antagonists of the excitatory amino acids on neurones of the rat spinal cord.

Authors: H McLennan; J Liu
Journal: Exp Brain Res Date: 1982 Impact factor: 1.972

4. Antagonism of the hypermotility response induced by excitatory amino acids in the rat nucleus accumbens.

Authors: B A Donzanti; N J Uretsky
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1984-01 Impact factor: 3.000

5. Blockade of amino acid-induced depolarizations and inhibition of excitatory post-synaptic potentials in rat dentate gyrus.

Authors: V Crunelli; S Forda; J S Kelly
Journal: J Physiol Date: 1983-08 Impact factor: 5.182

10. A microiontophoretic study on the nature of the putative synaptic neurotransmitter involved in the pedunculopontine-substantia nigra pars compacta excitatory pathway of the rat.

Authors: E Scarnati; A Proia; E Campana; C Pacitti
Journal: Exp Brain Res Date: 1986 Impact factor: 1.972

10 in total

Ranking of excitatory amino acids by the antagonists glutamic acid diethylester and D-alpha-aminoadipic acid.

1. A comparison between the in vivo and in vitro activity of five potent and competitive NMDA antagonists.

2. Inhibition of quisqualate-induced seizures by glutamic acid diethyl ester and anti-epileptic drugs.

3. The action of six antagonists of the excitatory amino acids on neurones of the rat spinal cord.

4. Antagonism of the hypermotility response induced by excitatory amino acids in the rat nucleus accumbens.

5. Blockade of amino acid-induced depolarizations and inhibition of excitatory post-synaptic potentials in rat dentate gyrus.

6. The antagonism of amino acid-induced excitations of rat hippocampal CA1 neurones in vitro.

7. Glutamate and aspartate agonists structurally related to ibotenic acid.

8. Excitatory amino acid receptor-mediated transmission of somatosensory evoked potentials in the rat thalamus.

9. A possible role of AA2 excitatory amino acid receptors in the expression of stimulant drug effects.

10. A microiontophoretic study on the nature of the putative synaptic neurotransmitter involved in the pedunculopontine-substantia nigra pars compacta excitatory pathway of the rat.