Literature DB >> 7435801

The genes for variant antigens in trypanosomes.

P Borst, A C Frasch, A Bernards, J H Hoeijmakers, L H Van der Ploeg, G A Cross.   

Abstract

We have studied the mechanism of antigenic variation by using DNA complementary to the messenger RNAs for four variant surface glycoproteins of Trypanosoma brucei. Pure complementary DNAs were obtained by cloning as recombinant DNA in Escherichia coli. Using these complementary DNAs as hybridization probes, we have analyzed the genes for these variant surface glycoproteins. The results provide new information on the origin and evolution of antigenic variation, and on the mechanism involved in switching from one antigenic type to another.

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Year:  1980        PMID： 7435801     DOI： 10.4269/ajtmh.1980.29.1033

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  8 in total

Review 1.  Molecular biology of trypanosome antigenic variation.

Authors:  J E Donelson; A C Rice-Ficht
Journal:  Microbiol Rev       Date:  1985-06

2.  Analysis of the DNA and RNA changes associated with the expression of isotypic variant-specific antigens of trypanosomes.

Authors:  E Pays; M Lheureux; M Steinert
Journal:  Nucleic Acids Res       Date:  1981-09-11       Impact factor: 16.971

3.  analysis of genomic rearrangements associated with two variable antigen genes of Trypanosoma brucei.

Authors:  J R Young; J E Donelson; P A Majiwa; S Z Shapiro; R O Williams
Journal:  Nucleic Acids Res       Date:  1982-02-11       Impact factor: 16.971

4.  Characterization of the DNA duplication-transposition that controls the expression of two genes for variant surface glycoproteins in Trypanosoma brucei.

Authors:  L H Van der Ploeg; A Bernards; F A Rijsewijk; P Borst
Journal:  Nucleic Acids Res       Date:  1982-01-22       Impact factor: 16.971

5.  Gene duplication and transposition linked to antigenic variation in Trypanosoma brucei.

Authors:  E Pays; N Van Meirvenne; D Le Ray; M Steinert
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205

6.  RNA splicing is required to make the messenger RNA for a variant surface antigen in trypanosomes.

Authors:  L H Van der Ploeg; A Y Liu; P A Michels; T De Lange; P Borst; H K Majumder; H Weber; G H Veeneman; J Van Boom
Journal:  Nucleic Acids Res       Date:  1982-06-25       Impact factor: 16.971

Review 7.  Life and times: synthesis, trafficking, and evolution of VSG.

Authors:  Paul T Manna; Cordula Boehm; Ka Fai Leung; Senthil Kumar Natesan; Mark C Field
Journal:  Trends Parasitol       Date:  2014-04-12

Review 8.  The Trypanosomal Transferrin Receptor of Trypanosoma Brucei-A Review.

Authors:  Christopher K Kariuki; Benoit Stijlemans; Stefan Magez
Journal:  Trop Med Infect Dis       Date:  2019-10-01
  8 in total

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