Literature DB >> 7435421

7 alpha-Dehydroxylation of cholic acid by cell extracts of Eubacterium species V.P.I. 12708.

P B Hylemon, A F Cacciapuoti, B A White, T R Whitehead, R J Fricke.   

Abstract

NADH:flavin oxidoreductase and 7 alpha-dehydroxylase were induced 5- and 90-fold, respectively, by cholic acid in cultures of Eubacterium species V.P.I. 12708. Assays of 7 alpha-dehydroxylase activity in the presence of various cofactors revealed that optimal activity was obtained in the presence of NAD+ plus FADH2. The pH optima of 7 alpha-dehydroxylase activity in whole cells and cell extracts were 7.0. The similar induction pattern of these two enzymes and the apparent cofactor requirements for 7 alpha-dehydroxylation suggest a relationship between 7 alpha-dehydroxylase and NADH:flavin oxidoreductase.

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Year:  1980        PMID： 7435421     DOI： 10.1093/ajcn/33.11.2507

Source DB:  PubMed          Journal:  Am J Clin Nutr        ISSN： 0002-9165            Impact factor:   7.045


  8 in total

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Journal:  Gut Microbes       Date:  2019-06-09

Review 2.  Deoxycholic acid and the pathogenesis of gall stones.

Authors:  S N Marcus; K W Heaton
Journal:  Gut       Date:  1988-04       Impact factor: 23.059

3.  Composition of cecal bile acids in ex-germfree mice inoculated with human intestinal bacteria.

Authors:  S Narushima; K Ito; K Kuruma; K Uchida
Journal:  Lipids       Date:  2000-06       Impact factor: 1.880

4.  7 alpha-Dehydroxylation of bile acids by resting cells of an unidentified, gram-positive, nonsporeforming anaerobic bacterium.

Authors:  N Masuda; H Oda
Journal:  Appl Environ Microbiol       Date:  1983-02       Impact factor: 4.792

5.  Transformation of bile acids and sterols by clostridia (fusiform bacteria) in Wistar rats.

Authors:  K Uchida; T Satoh; S Narushima; K Itoh; H Takase; K Kuruma; H Nakao; N Yamaga; K Yamada
Journal:  Lipids       Date:  1999-03       Impact factor: 1.880

6.  7 alpha-Dehydroxylation of bile acids by resting cells of a Eubacterium lentum-like intestinal anaerobe, strain c-25.

Authors:  N Masuda; H Oda; S Hirano; M Masuda; H Tanaka
Journal:  Appl Environ Microbiol       Date:  1984-04       Impact factor: 4.792

7.  Strain-Dependent Inhibition of Clostridioides difficile by Commensal Clostridia Carrying the Bile Acid-Inducible (bai) Operon.

Authors:  A D Reed; M A Nethery; A Stewart; R Barrangou; C M Theriot
Journal:  J Bacteriol       Date:  2020-05-11       Impact factor: 3.490

8.  Deoxycholic acid formation in gnotobiotic mice associated with human intestinal bacteria.

Authors:  Seiko Narushima; Kikuji Itoha; Yukiko Miyamoto; Sang-Hee Park; Keiko Nagata; Kazuo Kuruma; Kiyohisa Uchida
Journal:  Lipids       Date:  2006-09       Impact factor: 1.646
  8 in total

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