Literature DB >> 7435167

Neurofibrillary degeneration in cultured adult mouse neurons induced by maytansine.

S U Kim, M Tomonaga, B Ghetti.   

Abstract

The effects of maytansine, an antimitotic compound isolated from an African plant, were studied by light and electron microscopy in dissociated cell cultures of adult mouse dorsal root ganglia. Maytansine at 10-100 ng/ml concentration caused reversible, concentration-dependent, inhibition of microtubule assembly and induction of a large amount of 10 nm filaments in the cytoplasm of cultured neurons and Schwann cells.

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Year:  1980        PMID： 7435167     DOI： 10.1007/bf00688016

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN： 0001-6322            Impact factor:   17.088


  11 in total

Review 1.  Action of drugs on microtubules.

Authors:  L Wilson
Journal:  Life Sci       Date:  1975-08-01       Impact factor: 5.037

2.  EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION 2. ELECTRON MICROSCOPY, PHOSPHATASE HISTOCHEMISTRY AND ELECTRON PROBE ANALYSIS.

Authors:  R D TERRY; C PENA
Journal:  J Neuropathol Exp Neurol       Date:  1965-04       Impact factor: 3.685

3.  EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION. I. LIGHT MICROSCOPIC OBSERVATIONS.

Authors:  I KLATZO; H WISNIEWSKI; E STREICHER
Journal:  J Neuropathol Exp Neurol       Date:  1965-04       Impact factor: 3.685

4.  Adult mouse dorsal root ganglia neurons in cell culture.

Authors:  B S Scott
Journal:  J Neurobiol       Date:  1977-09

5.  Tissue culture of adult human neurons.

Authors:  S U Kim; K G Warren; M Kalia
Journal:  Neurosci Lett       Date:  1979-02       Impact factor: 3.046

6.  Neurofibrillary spheroids induced by aluminum phosphate in dorsal root ganglia neurons in vitro.

Authors:  F J Seil; P W Lampert; I Klatzo
Journal:  J Neuropathol Exp Neurol       Date:  1969-01       Impact factor: 3.685

7.  Neurofibrillary tangles induced by vincristine and vinblastine sulfate in central and peripheral neurons in vitro.

Authors:  F J Seil
Journal:  Exp Neurol       Date:  1968-06       Impact factor: 5.330

8.  Intermediate filaments as mechanical integrators of cellular space.

Authors:  E Lazarides
Journal:  Nature       Date:  1980-01-17       Impact factor: 49.962

9.  Induction of neurofibrillary degeneration following treatment with maytansine in vivo.

Authors:  B Ghetti
Journal:  Brain Res       Date:  1979-03-09       Impact factor: 3.252

10.  Effects of mitotic spindle inhibitors on neurotubules and neurofilaments in anterior horn cells.

Authors:  H Wisniewski; M L Shelanski; R D Terry
Journal:  J Cell Biol       Date:  1968-07       Impact factor: 10.539
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  2 in total

Review 1.  Neuronal aging in tissue and cell cultures: a review.

Authors:  S U Kim
Journal:  In Vitro       Date:  1983-02

2.  Spontaneous lower motor neuron disease with neurofibrillary accumulation in young pigs.

Authors:  R J Higgins; D M Rings; W R Fenner; S Stevenson
Journal:  Acta Neuropathol       Date:  1983       Impact factor: 17.088
  2 in total

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