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Literature DB >> 7433331

Hypersensitivity and jaundice due to azathioprine.

Abstract

A patient is described who suffered hypersenitivity reactions (anorexia, nausea and vomiting) as well as cholestatic jaundice from therapy with azathioprine. Evidence is given that the 2 reactions were mediated by different portions of the azathioprine molecule.

Entities: Chemical Disease Species

Mesh：

Substances：
Azathioprine

Year: 1980 PMID： 7433331 PMCID： PMC2425876 DOI： 10.1136/pgmj.56.654.274

Source DB: PubMed Journal: Postgrad Med J ISSN： 0032-5473 Impact factor: 2.401

11 in total

1. Hepatitis in association with prolonged 6-mercaptopurine therapy.

Authors: S K McILVANIE; J D MACCARTHY
Journal: Blood Date: 1959-01 Impact factor: 22.113

2. Sensitivity to azathioprine.

Authors: J O King; M C Laver; K F Fairley; G A Ames
Journal: Med J Aust Date: 1972-10-21 Impact factor: 7.738

3. Controlled trial of azathioprine in Crohn's disease.

Authors: J M Willoughby; J Beckett; P J Kumar; A M Dawson
Journal: Lancet Date: 1971-10-30 Impact factor: 79.321

4. Acute pancreatitis as a complication of Imuran therapy in regional enteritis.

Authors: J R Nogueira; M A Freedman
Journal: Gastroenterology Date: 1972-05 Impact factor: 22.682

5. Azathioprine: an adjunct to surgical therapy of granulomatous enteritis.

Authors: W R Drucker; K N Jeejeebhoy
Journal: Ann Surg Date: 1970-10 Impact factor: 12.969

Review 6. Azathioprine therapy of "autoimmune" diseases.

Authors: C C Corley; H E Lessner; W E Larsen
Journal: Am J Med Date: 1966-09 Impact factor: 4.965

7. Azathioprine therapy for inflammatory bowel disease. A preliminary report.

Authors: C H Brown; E Achkar
Journal: Am J Gastroenterol Date: 1970-10 Impact factor: 10.864

8. The treatment of active chronic hepatitis with 6-mercaptopurine and azathioprine.

Authors: S P Mistilis; C R Blackburn
Journal: Australas Ann Med Date: 1967-11

9. Azathioprine treatment of immunological renal disease.

Authors: D A Adams; A Gordon; M H Maxwell
Journal: JAMA Date: 1967-02-13 Impact factor: 56.272

10. Intrahepatic cholestasis due to azathioprine.

Authors: M Sparberg; N Simon; F del Greco
Journal: Gastroenterology Date: 1969-10 Impact factor: 22.682

18 in total

1. Severe cholestasis due to azathioprine in Behcet's disease.

Authors: Kadir Gisi; Murat Ispiroglu; Bulent Kantarceken; Hamide Sayar
Journal: BMJ Case Rep Date: 2019-03-31

2. Azathioprine shock.

Authors: E Rosenthal
Journal: Postgrad Med J Date: 1986-07 Impact factor: 2.401

Review 3. Clinical associations between arthritis and liver disease.

Authors: P R Mills; R D Sturrock
Journal: Ann Rheum Dis Date: 1982-06 Impact factor: 19.103

Review 4. Understanding the Cautions and Contraindications of Immunomodulator and Biologic Therapies for Use in Inflammatory Bowel Disease.

Authors: H Matthew Cohn; Maneesh Dave; Edward V Loftus
Journal: Inflamm Bowel Dis Date: 2017-08 Impact factor: 5.325

Review 9. Drug-induced cholestasis.

Authors: H J Zimmerman; J H Lewis
Journal: Med Toxicol Date: 1987 Mar-Apr

10. Hypersensitivity to azathioprine in myasthenia gravis.

Authors: G F Watts; R Corston
Journal: Postgrad Med J Date: 1984-05 Impact factor: 2.401