Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The effect of lidocaine on the processing of soluble immune aggregates and immune complexes by peritoneal macrophages.

Literature DB >> 7429552

The effect of lidocaine on the processing of soluble immune aggregates and immune complexes by peritoneal macrophages.

A Hijlstra, W Van Dorp, M R Daha, G Q Leslie.

Abstract

In a search for new techniques which would specifically identify the various steps of the handling of immune complexes by macrophages the local anaesthetic, lidocaine, was investigated. Lidocaine was shown to inhibit selectively the digestion of immune complexes and immunoglobulin aggregates by macrophages whereas it had little effect on the binding or ingestion steps. Due to the reversible inhibitory effect of lidocaine, this drug may be used in future studies to assess the role of extracellular stimuli on the fate of intracellular immune complexes.

Entities: Chemical

Mesh：

Substances：

Year: 1980 PMID： 7429552 PMCID： PMC1458221

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

12 in total

Review 1. Endocytosis.

Authors: S C Silverstein; R M Steinman; Z A Cohn
Journal: Annu Rev Biochem Date: 1977 Impact factor: 23.643

2. The products from papain and pepsin hydrolyses of guinea-pig immunoglobulins gamma 1G and gamma 2 G.

Authors: R G Leslie; M D Melamed; S Cohen
Journal: Biochem J Date: 1971-03 Impact factor: 3.857

3. Local anesthetic inhibition of phagocytosis and metabolism of human leukocytes.

Authors: B F Cullen; R H Haschke
Journal: Anesthesiology Date: 1974-02 Impact factor: 7.892

4. Binding of affinity cross-linked oligomers of IgG to cells bearing Fc receptors.

Authors: D M Segal; E Hurwitz
Journal: J Immunol Date: 1977-04 Impact factor: 5.422

5. Enhanced degradation of soluble immunoglobulin aggregates by macrophages in the presence of complement.

Authors: A Kijlstra; L A Van Es; M R Daha
Journal: Immunology Date: 1979-07 Impact factor: 7.397

6. Cell to substrate adhesion and spreading: inhibition by cationic anesthetics.

Authors: M Rabinovitch; M DeStefano
Journal: J Cell Physiol Date: 1975-04 Impact factor: 6.384

7. Local anesthetics affect transmembrane cytoskeletal control of mobility and distribution of cell surface receptors.

Authors: G Poste; D Papahadjopoulos; G L Nicolson
Journal: Proc Natl Acad Sci U S A Date: 1975-11 Impact factor: 11.205

8. Mechanisms underlying binding of immune complexes to macrophages.

Authors: J M Phillips-Quagliata; B B Levine; F Quagliata; J W Uhr
Journal: J Exp Med Date: 1971-03-01 Impact factor: 14.307

9. Influence of local anesthetics upon human polymorphonuclear leukocyte function in vitro. Reduction of lysosomal enzyme release and superoxide anion production.

Authors: I M Goldstein; S Lind; S Hoffstein; G Weissmann
Journal: J Exp Med Date: 1977-08-01 Impact factor: 14.307

5. Macrophages pulsed with Streptococcus pneumoniae elicit a T cell-dependent antibody response upon transfer into naive mice.

Authors: Sam Vasilevsky; Jesus Colino; Roman Puliaev; David H Canaday; Clifford M Snapper
Journal: J Immunol Date: 2008-08-01 Impact factor: 5.422

5 in total

The effect of lidocaine on the processing of soluble immune aggregates and immune complexes by peritoneal macrophages.

Review 1. Endocytosis.

2. The products from papain and pepsin hydrolyses of guinea-pig immunoglobulins gamma 1G and gamma 2 G.

3. Local anesthetic inhibition of phagocytosis and metabolism of human leukocytes.

4. Binding of affinity cross-linked oligomers of IgG to cells bearing Fc receptors.

5. Enhanced degradation of soluble immunoglobulin aggregates by macrophages in the presence of complement.

6. Cell to substrate adhesion and spreading: inhibition by cationic anesthetics.

7. Local anesthetics affect transmembrane cytoskeletal control of mobility and distribution of cell surface receptors.

8. Mechanisms underlying binding of immune complexes to macrophages.

9. Influence of local anesthetics upon human polymorphonuclear leukocyte function in vitro. Reduction of lysosomal enzyme release and superoxide anion production.

10. Association and dissociation of aggregated IgG from rat peritoneal macrophages.

1. Flow cytometric analysis of pulmonary lymphocytes from mice infected with respiratory syncytial virus.

2. [The effect of anaesthesia and surgery on immune function. A review (author's transl)].

3. Enhanced alternative complement pathway-dependent degradation of soluble immunoglobulin aggregates by macrophages.

4. Impairment of raw 264.7 macrophage function by antiarrhythmic drugs.

5. Macrophages pulsed with Streptococcus pneumoniae elicit a T cell-dependent antibody response upon transfer into naive mice.