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Literature DB >> 74287

A joint produce of the genes gag and pol of avian sarcoma virus: a possible precursor of reverse transcriptase.

H Oppermann, J M Bishop, H E Varmus, L Levintow.

Abstract

A virus-specific protein of approximately 180,000 daltons has been identified in cells transformed by avian sarcoma virus. The protein, designated P180, includes immunological determinants of both viral core proteins and reverse transcriptase. Its tryptic peptides represent essentially the sum of those of the precursor of the core proteins (Pr76gag) and reverse transcriptase. Thus P180 must arise from the uninterrupted translation of gag and pol. The kinetics of its formation and decay suggest that P180 is the precursor of reverse transcriptase.

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Year: 1977 PMID： 74287 DOI： 10.1016/0092-8674(77)90164-7

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

69 in total

1. Replication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase.

Authors: J G Julias; A L Ferris; P L Boyer; S H Hughes
Journal: J Virol Date: 2001-07 Impact factor: 5.103

2. Evidence for the identity of shared 5'-terminal sequences between genome RNA and subgenomic mRNA's of B77 avian sarcoma virus.

Authors: C M Stoltzfus; L K Kuhnert
Journal: J Virol Date: 1979-11 Impact factor: 5.103

3. Morphological revertants of an avian sarcoma virus-transformed mammalian cell line exhibit tumorigenicity and contain pp60src.

Authors: A F Lau; R A Krzyzek; J S Brugge; R L Erikson; J Schollmeyer; A J Faras
Journal: Proc Natl Acad Sci U S A Date: 1979-08 Impact factor: 11.205

4. Isolation and characterization of a mouse cell line containing a defective Moloney murine leukemia virus genome.

Authors: P Besmer; H Fan; M Paskind; D Baltimore
Journal: J Virol Date: 1979-03 Impact factor: 5.103

5. Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src).

Authors: H Oppermann; A D Levinson; H E Varmus; L Levintow; J M Bishop
Journal: Proc Natl Acad Sci U S A Date: 1979-04 Impact factor: 11.205

6. In vitro, the major ribosome binding site on Rous sarcoma virus RNA does not contain the nucleotide sequence coding for the N-terminal amino acids of the gag gene product.

Authors: J L Darlix; P F Spahr; P A Bromley; J C Jaton
Journal: J Virol Date: 1979-02 Impact factor: 5.103

A joint produce of the genes gag and pol of avian sarcoma virus: a possible precursor of reverse transcriptase.

1. Replication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase.

2. Evidence for the identity of shared 5'-terminal sequences between genome RNA and subgenomic mRNA's of B77 avian sarcoma virus.

3. Morphological revertants of an avian sarcoma virus-transformed mammalian cell line exhibit tumorigenicity and contain pp60src.

4. Isolation and characterization of a mouse cell line containing a defective Moloney murine leukemia virus genome.

5. Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src).

6. In vitro, the major ribosome binding site on Rous sarcoma virus RNA does not contain the nucleotide sequence coding for the N-terminal amino acids of the gag gene product.

7. Extracellular cleavage of the glycoprotein precursor of Rous sarcoma virus.

8. Biochemical properties of p15-associated protease in an avian RNA tumor virus.

9. Role of the avian retroviral protease in the activation of reverse transcriptase during virion assembly.

10. Expression of the cauliflower mosaic virus capsid gene in vivo.