Literature DB >> 7426830

Metergoline and cyproheptadine suppress prolactin release by a non-5-hydroxytryptaminergic, non-dopaminergic mechanism.

G M Besser, G Delitala, A Grossman, T Yeo.   

Abstract

A dispersed rat anterior pituitary cell system has been used to investigate the effects of cyproheptadine and metergoline on prolactin secretion. Both drugs were potent inhibitors of prolactin secretion. However, the inhibition was not antagonized by either 5-hydroxytryptamine or a variety of dopamine antagonists. We conclude that both drugs act through mechanisms that are neither 5-hydroxytryptaminergic nor dopaminergic.

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Year:  1980        PMID： 7426830      PMCID： PMC2044372          DOI： 10.1111/j.1476-5381.1980.tb10896.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  7 in total

Review 1.  Multiple receptors for dopamine.

Authors:  J W Kebabian; D B Calne
Journal:  Nature       Date:  1979-01-11       Impact factor: 49.962

2.  Dopaminergic receptors in the anterior pituitary gland. Correlation of [3H]dihydroergocryptine binding with the dopaminergic control of prolactin release.

Authors:  M G Caron; M Beaulieu; V Raymond; B Gagné; J Drouin; R J Lefkowitz; F Labrie
Journal:  J Biol Chem       Date:  1978-04-10       Impact factor: 5.157

Review 3.  The substituted benzamides--a novel class of dopamine antagonists.

Authors:  P Jenner; C D Marsden
Journal:  Life Sci       Date:  1979-08-06       Impact factor: 5.037

4.  Mechanisms underlying the prolactin-lowering effect of meterogoline in the rat.

Authors:  D Cocchi; V Locatelli; R Carminati; E E Müller
Journal:  Life Sci       Date:  1978-09-04       Impact factor: 5.037

5.  Effects of cyproheptadine on prolactin synthesis and release by normal and suppressed pituitary glands and by dispersed pituitary tumor cells.

Authors:  S W Lamberts; R M MacLeod
Journal:  Endocrinology       Date:  1978-11       Impact factor: 4.736

6.  Growth hormone and prolactin release in acromegalic patients following metergoline administration.

Authors:  G Delitala; A Masala; S Alagna; L Devilla; G Lotti
Journal:  J Clin Endocrinol Metab       Date:  1976-12       Impact factor: 5.958

7.  Effects of gamma-aminobutyric acid and histamine on prolactin secretion in the rat.

Authors:  C Rivier; W Vale
Journal:  Endocrinology       Date:  1977-08       Impact factor: 4.736
  7 in total
  1 in total

1.  Intolerance of bromocriptine: is metergoline a satisfactory alternative?

Authors:  I F Casson; B A Walker; L J Hipkin; P E Belchetz
Journal:  Br Med J (Clin Res Ed)       Date:  1985-06-15
  1 in total

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