Literature DB >> 7426650

Application of differential spectra in the ultraviolet-visible region to study the formation of amphotericin B-sterol complexes.

I Gruda, P Nadeau, J Brajtburg, G Medoff.   

Abstract

The extent of complex formation between the polyene antibiotic, amphotericin B, and cholesterol or ergosterol was investigated and a method for a quantitative measurement of the complex formation was developed. The effect of experimental conditions on the magnitude of the amphotericin B-sterol interaction and on the selectivity of this interaction showed that there was only a narrow range of solvent composition in which the differential selectivity of amphotericin B towards these two sterols could be observed.

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Year:  1980        PMID： 7426650     DOI： 10.1016/0005-2736(80)90309-0

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  9 in total

Review 1.  Amphotericin B: delivery systems.

Authors:  J Brajtburg; W G Powderly; G S Kobayashi; G Medoff
Journal:  Antimicrob Agents Chemother       Date:  1990-03       Impact factor: 5.191

Review 2.  Amphotericin B: current understanding of mechanisms of action.

Authors:  J Brajtburg; W G Powderly; G S Kobayashi; G Medoff
Journal:  Antimicrob Agents Chemother       Date:  1990-02       Impact factor: 5.191

3.  Ion coordination in the amphotericin B channel.

Authors:  V Khutorsky
Journal:  Biophys J       Date:  1996-12       Impact factor: 4.033

4.  Effect of fasting on temporal variation in the nephrotoxicity of amphotericin B in rats.

Authors:  M LeBrun; L Grenier; M G Bergeron; L Thibault; G Labrecque; D Beauchamp
Journal:  Antimicrob Agents Chemother       Date:  1999-03       Impact factor: 5.191

5.  Relative avidity of etruscomycin to cholesterol and ergosterol.

Authors:  P Nedeau; I Gruda; G Medoff; J Brajtburg
Journal:  Antimicrob Agents Chemother       Date:  1982-04       Impact factor: 5.191

6.  Treatment of murine cryptococcal meningitis with an SCH 39304-amphotericin B combination.

Authors:  M M Albert; J R Graybill; M G Rinaldi
Journal:  Antimicrob Agents Chemother       Date:  1991-09       Impact factor: 5.191

Review 7.  In search of the holy grail of antifungal therapy.

Authors:  Stanley W Chapman; Donna C Sullivan; John D Cleary
Journal:  Trans Am Clin Climatol Assoc       Date:  2008

8.  Increase in colony-forming units of Candida albicans after treatment with polyene antibiotics.

Authors:  J Brajtburg; S Elberg; G Medoff; G S Kobayashi
Journal:  Antimicrob Agents Chemother       Date:  1981-01       Impact factor: 5.191

9.  Antifungal activity of eugenol analogues. Influence of different substituents and studies on mechanism of action.

Authors:  Héctor Carrasco; Marcela Raimondi; Laura Svetaz; Melina Di Liberto; María V Rodriguez; Luis Espinoza; Alejandro Madrid; Susana Zacchino
Journal:  Molecules       Date:  2012-01-19       Impact factor: 4.411
  9 in total

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