Literature DB >> 7426437

In vitro effect of cyclophosphamide metabolites on chromosomes of Fanconi anaemia patients.

R Berger, A Bernheim, E Gluckman, C Gisselbrecht.   

Abstract

The effect of cyclophosphamide metabolites was studied on chromosomes of FAnconi anaemia patients, parents and controls. A high susceptibility of Fa patients chromosomes was observed when low concentrations of sera of a cyclophosphamide-treated patient was added to PHA-stimulated lymphocyte cultures. No effect was observed with comparable concentrations on cells from FA parents or controls. The high susceptibility of FA cells is discussed in relation to the high sensitivity of FA patients to cyclophosphamide when used as a conditioning drug for bone marrow graft.

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Year:  1980        PMID： 7426437     DOI： 10.1111/j.1365-2141.1980.tb07179.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  16 in total

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2.  Interleukin 8/KC enhances G-CSF induced hematopoietic stem/progenitor cell mobilization in Fancg deficient mice.

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Review 3.  Hematopoietic cell transplantation in Fanconi anemia: current evidence, challenges and recommendations.

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Journal:  Expert Rev Hematol       Date:  2016-12-21       Impact factor: 2.929

Review 4.  Cytogenomics of cancers: from chromosome to sequence.

Authors:  Alain Bernheim
Journal:  Mol Oncol       Date:  2010-06-11       Impact factor: 6.603

5.  No chromosome arm unturned: in memory of Roland Berger 1934-2012.

Authors:  C J Harrison; J D Rowley; H Van den Berghe; A Bernheim; M Martineau; M Gautier; M Le Coniat-Busson; S Romana; N Dastugue; A Hagemeijer; P Jonveaux; F Nguyen-Khac; O A Bernard
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6.  Alternative donor hematopoietic cell transplantation for Fanconi anemia.

Authors:  Margaret L MacMillan; Todd E DeFor; Jo-Anne H Young; Kathryn E Dusenbery; Bruce R Blazar; Arne Slungaard; Heather Zierhut; Daniel J Weisdorf; John E Wagner
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7.  Proceedings of the Annual Meeting of the European Foundation for Bone Marrow Transplantation, Sils Maria (Engadine), Switzerland, April 13-16, 1980.

Authors: 
Journal:  Blut       Date:  1980-09

8.  Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia.

Authors:  John E Wagner; Mary Eapen; Margaret L MacMillan; Richard E Harris; Ricardo Pasquini; Farid Boulad; Mei-Jie Zhang; Arleen D Auerbach
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9.  Differential sensitivity of Fanconi anaemia lymphocytes to the clastogenic action of cis-diamminedichloroplatinum (II) and trans-diamminedichloroplatinum (II).

Authors:  E H Poll; F Arwert; H Joenje; A H Wanamarta
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

10.  In vitro effect of fludarabine, cyclophosphamide, and cytosine arabinoside on chromosome breakage in Fanconi anemia patients: relevance to stem cell transplantation.

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Journal:  Int J Hematol       Date:  2007-05       Impact factor: 2.490
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