| Literature DB >> 7426422 |
P J Frosch, S Duncan, A M Kligman.
Abstract
The wealing response of human skin to dimethyl sulphoxide (DMSO) has been quantified. Concentrations of 90%, 95% and 100% were applied for 5 min circular areas 8 min in diameter. Wealing was scored on a five-point scale after 10 min. Marked individual variations were found. Wealing was strongly influenced by body region and was dose-dependent. The intensity of the reaction paralleled that to other irritants and was dependent mainly on thickness and integrity of the horny layer. The DMSO test is a simple, quick way to assess the barrier function of the stratum corneum.Entities:
Mesh：
Substances：
Year: 1980 PMID： 7426422 DOI： 10.1111/j.1365-2133.1980.tb07243.x
Source DB: PubMed Journal: Br J Dermatol ISSN： 0007-0963 Impact factor: 9.302