Literature DB >> 7426381

Effects of hyperthermia on radiosensitivity of normal and leukaemic lymphocytes.

R Schrek, S S Stefani.   

Abstract

We measured the effects of X-irradiation plus incubation at elevated temperatures on peripheral blood lymphocytes from normal persons and from patients with chronic lymphocytic leukaemia. Counts of viable lymphocytes were based on morphological characteristics by phase microscopy. Dose-effect curves for X-irradiation were biphasic. The D0S for lymphocytes incubated at 39 and 41 degrees were significantly less than the D0 for 37 degrees. For both normal and leukaemia lymphocytes, X-irradiation was synergistic with hyperthermia at 39 degrees and 41 degrees.

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Mesh：

Year:  1980        PMID： 7426381      PMCID： PMC2041584     

Source DB:  PubMed          Journal:  Br J Exp Pathol        ISSN： 0007-1021


  8 in total

1.  Thermally enhanced radioresponse of cultured Chinese hamster cells: inhibition of repair of sublethal damage and enhancement of lethal damage.

Authors:  E Ben-Hur; M M Elkind; B V Bronk
Journal:  Radiat Res       Date:  1974-04       Impact factor: 2.841

2.  Clinical evaluation of an in vitro test for radiosensitivity of leukemic lymphocytes.

Authors:  R SCHREK; S L LEITHOLD; I A FRIEDMAN; W R BEST
Journal:  Blood       Date:  1962-10       Impact factor: 22.113

3.  Cinemicrographic observations and theoretical considerations on reactions of lymphocytes to x-rays.

Authors:  R SCHREK
Journal:  Radiology       Date:  1955-12       Impact factor: 11.105

4.  Radiosensitivity of human lymphocytes and thymocytes.

Authors:  D K Kwan; A Norman
Journal:  Radiat Res       Date:  1977-01       Impact factor: 2.841

5.  Thermal sensitivity and the effect of elevated temperatures on the radiation sensitivity of Chinese hamster cells.

Authors:  J E Robinson; M J Wizenberg
Journal:  Acta Radiol Ther Phys Biol       Date:  1974-06

Review 6.  Prospects for hyperthermia in human cancer therapy. Part II: implications of biological and physical data for applications of hyperthermia to man.

Authors:  W G Connor; E W Gerner; R C Miller; M L Boone
Journal:  Radiology       Date:  1977-05       Impact factor: 11.105

7.  Sensitivity of normal and leukemic lymphocytes and leukemic myeloblasts to heat.

Authors:  R Schrek
Journal:  J Natl Cancer Inst       Date:  1966-11       Impact factor: 13.506

8.  The effect of hyperthermia and melphalan on survival of human fibroblast strains and melanoma cell lines.

Authors:  P Goss; P G Parsons
Journal:  Cancer Res       Date:  1977-01       Impact factor: 12.701
  8 in total

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