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Literature DB >> 74258

Enhancement by cytotoxic agents of artificial pulmonary metastasis.

Abstract

The formation of lung colonies by i.v. injected Lewis lung-tumour cells in syngeneic recipients was greatly enhanced by prior treatment of the mice with cyclophosphamide. The lung-cloning efficiency was linearly related to cyclophosphamide dose and the optimum time of treatment was 2-4 days before the injection of tumour cells. The resulting lung colonies had a similar size distribution to colonies in untreated recipients. Bleomycin, local thoraric irradiation and whole-body irradiation were much less effective in enhancing the lung-cloning efficiency. Cyclophosphamide also enhanced the take probability of i.m. implanted tumour cells.

Entities: Chemical Disease Species

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Year: 1977 PMID： 74258 PMCID： PMC2025565 DOI： 10.1038/bjc.1977.247

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

11 in total

1. Stem-cell survival and tumor control in the Lewis lung carcinoma.

Authors: G G Steel; K Adams
Journal: Cancer Res Date: 1975-06 Impact factor: 12.701

2. Potentiating effect of prior local irradiation of the lungs on pulmonary metastases.

Authors: H A van den Brenk; H Kelly
Journal: Br J Radiol Date: 1974-06 Impact factor: 3.039

3. Influence of preirradiation of lung on development of artificial pulmonary metastases of fibrosarcoma in mice.

Authors: H R Withers; L Milas
Journal: Cancer Res Date: 1973-08 Impact factor: 12.701

4. The effect of lung irradiation on the incidence of pulmonary metastases in mice.

Authors: J M Brown
Journal: Br J Radiol Date: 1973-08 Impact factor: 3.039

5. A lung-colony assay to determine the radiosensitivity of cells of a solid tumour.

Authors: R P Hill; R S Bush
Journal: Int J Radiat Biol Relat Stud Phys Chem Med Date: 1969-07

6. The influence of nitrogen mustard upon the establishment of lung metastases following injection of intravenous autologous cells in the benzo(a)pyrene-induced rat fibrosarcoma.

Authors: L M Cobb
Journal: Int J Cancer Date: 1968-07-15 Impact factor: 7.396

7. The lung-colony assay: extension to the Lewis lung tumour and the B16 melanoma--radiosensitivity of B16 melanoma cells.

Authors: R P Hill; J A Stanley
Journal: Int J Radiat Biol Relat Stud Phys Chem Med Date: 1975-04

Review 8. Techniques for inhibiting tumor metastases.

Authors: H C Hoover; A S Ketcham
Journal: Cancer Date: 1975-01 Impact factor: 6.860

9. Sclerosing alveolitis induced by cyclophosphamide. Ultrastructural observations on alveolar injury and repair.

Authors: V E Gould; J Miller
Journal: Am J Pathol Date: 1975-12 Impact factor: 4.307

10. The influence of fibrin formation on the transplantability of murine tumour cells: implications for the mechanism of the Révész effect.

Authors: L J Peters; H B Hewitt
Journal: Br J Cancer Date: 1974-04 Impact factor: 7.640

14 in total

Enhancement by cytotoxic agents of artificial pulmonary metastasis.

1. Stem-cell survival and tumor control in the Lewis lung carcinoma.

2. Potentiating effect of prior local irradiation of the lungs on pulmonary metastases.

3. Influence of preirradiation of lung on development of artificial pulmonary metastases of fibrosarcoma in mice.

4. The effect of lung irradiation on the incidence of pulmonary metastases in mice.

5. A lung-colony assay to determine the radiosensitivity of cells of a solid tumour.

6. The influence of nitrogen mustard upon the establishment of lung metastases following injection of intravenous autologous cells in the benzo(a)pyrene-induced rat fibrosarcoma.

7. The lung-colony assay: extension to the Lewis lung tumour and the B16 melanoma--radiosensitivity of B16 melanoma cells.

Review 8. Techniques for inhibiting tumor metastases.

9. Sclerosing alveolitis induced by cyclophosphamide. Ultrastructural observations on alveolar injury and repair.

10. The influence of fibrin formation on the transplantability of murine tumour cells: implications for the mechanism of the Révész effect.

1. Influence of tumour size on radiosensitization by misonidazole.

Review 2. Interactions between cancer cells and the microvasculature: a rate-regulator for metastasis.

3. Local recurrence and metastasis of excised breast carcinoma in the rat.

4. Preferential growth of metastatic tumors at the pleural surface of mouse lung.

Review 5. Can cancer chemotherapy enhance the malignant behaviour of tumours?

6. The effectiveness of cis-platinum, cyclophosphamide and melphalan in treating disseminated tumor cells in mice.

7. The effects of oxygen radical--mediated pulmonary endothelial damage on cancer metastasis.

8. Effects of prolonged treatment with decarbazine on tumor metastatic potential in mice bearing Lewis lung carcinoma.

9. Role of natural killer cells in control of cancer metastasis.

10. Enhanced experimental metastatic capacity of a murine melanoma following pre-treatment with anticancer drugs.