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Literature DB >> 7424909

Genetic polymorphism of human erythrocyte glyoxalase II.

Abstract

A new method for the detection of glyoxalase II (hydroxyacylglutathione hydrolase) after starch gel electrophoresis is described. A survey of Asian-Pacific populations indicates that genetic polymorphism of glyoxalase II is extremely rare. Polymorphism was observed only in a Micronesian population from the island of Nauru, in which the frequency of the new variant allele HAGH2 was found to be .016. The electrophoretic pattern in heterozygotes was a double band, suggesting that the structure of glyoxalase II is monomeric.

Entities: Chemical Gene Species

Mesh：

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Year: 1980 PMID： 7424909 PMCID： PMC1686103

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

7 in total

1. Polymorphism of red cell glyoxalase 1. With special reference to South and Southeast Asia and Oceania.

Authors: A K Ghosh
Journal: Hum Genet Date: 1977-11-02 Impact factor: 4.132

2. Purification and characterization of S-2-hydroxyacylglutathione hydrolase (glyoxalase II) from human liver.

Authors: L Uotila
Journal: Biochemistry Date: 1973-09-25 Impact factor: 3.162

3. Starch-gel electrophoresis of four enzymes from human red blood cells: glyceraldehyde-3-phosphate dehydrogenase, fructoaldolase, glyoxalase II and sorbitol dehydrogenase.

Authors: D Charlesworth
Journal: Ann Hum Genet Date: 1972-04 Impact factor: 1.670

7. Polymorphism of red cell glyoxalase I (EI: 4.4.1.5); a new genetic marker in man. Investigation of 169 mother-child combinations.

Authors: J Kömpf; S Bissbort; S Gussmann; H Ritter
Journal: Humangenetik Date: 1975

7 in total

5 in total

Review 1. The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life.

Authors: P J Thornalley
Journal: Biochem J Date: 1990-07-01 Impact factor: 3.857

Genetic polymorphism of human erythrocyte glyoxalase II.

1. Polymorphism of red cell glyoxalase 1. With special reference to South and Southeast Asia and Oceania.

2. Purification and characterization of S-2-hydroxyacylglutathione hydrolase (glyoxalase II) from human liver.

3. Starch-gel electrophoresis of four enzymes from human red blood cells: glyceraldehyde-3-phosphate dehydrogenase, fructoaldolase, glyoxalase II and sorbitol dehydrogenase.

4. Erythrocyte glyoxalase II deficiency with coincidental hereditary elliptocytosis.

5. Human red cell glyoxalase I polymorphism.

6. Glutathione thiol esterases of human red blood cells. Fractionation by gel electrophoresis and isoelectric focusing.

7. Polymorphism of red cell glyoxalase I (EI: 4.4.1.5); a new genetic marker in man. Investigation of 169 mother-child combinations.

Review 1. The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life.

2. Further electrophoretic studies of erythrocyte glutathione peroxidase.

3. New regional localisations for HAGH and PGP on human chromosome 16.

4. Assignment of the glyoxalase II gene (HAGH) to human chromosome 16.

5. Genetics of diabetes in Nauru: effects of foreign admixture, HLA antigens and the insulin-gene-linked polymorphism.